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Related Experiment Video

Updated: Sep 27, 2025

Author Spotlight: A Pseudotype Virus System for Assessing Omicron Subvariants and Neutralizing Antibodies in SARS-CoV-2 Research

Author Spotlight: A Pseudotype Virus System for Assessing Omicron Subvariants and Neutralizing Antibodies in SARS-CoV-2 Research

Published on: September 8, 2023

Small form factor flow virometer for SARS-CoV-2.

Rubaiya Hussain^1,2, Alfredo E Ongaro^1,2,3, Maria L Rodriguez de la Concepción^4,2

¹ICFO-Institut de Ciències Fotòniques, The Barcelona Institute of Science and Technology, 08860, Castelldefels (Barcelona), Spain.

Biomedical Optics Express

|April 13, 2022

Summary

This summary is machine-generated.

A new flow-virometry reader offers rapid and sensitive detection of SARS-CoV-2 in saliva. This optofluidic technology provides a robust, low-cost alternative to current severe acute respiratory syndrome coronavirus 2 diagnostic tests.

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Last Updated: Sep 27, 2025

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Published on: January 12, 2024

Area of Science:

Biomedical Engineering
Infectious Disease Diagnostics
Optofluidics

Background:

Current severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) diagnostics, such as RT-PCR and antigen tests, have limitations including long turnaround times, high costs, and low sensitivity.
There is a critical need for rapid, sensitive, robust, and affordable methods for SARS-CoV-2 detection, particularly for point-of-care applications.

Purpose of the Study:

To introduce and validate a novel optofluidic technology, the flow-virometry reader (FVR), for the rapid and reliable detection of SARS-CoV-2 in saliva.
To present FVR as a viable alternative to existing diagnostic methods for severe acute respiratory syndrome coronavirus 2.

Main Methods:

Development of a flow-virometry reader (FVR) utilizing a microfluidic chip and a laser-pumped optical head.
Detection of SARS-CoV-2 viruses in saliva samples tagged with fluorescent antibodies.
Validation of the FVR technology using clinical samples.

Main Results:

The FVR technology demonstrated high sensitivity (91.2%) and specificity (90%) in detecting SARS-CoV-2.
The system offers a short time-to-result of less than 30 minutes.
The reader has a compact size (25 × 30 × 13 cm), suitable for point-of-care use.

Conclusions:

The developed flow-virometry reader is a promising rapid, sensitive, and cost-effective diagnostic tool for SARS-CoV-2.
Its portability and speed make it particularly suitable for point-of-care settings and resource-limited environments.
FVR presents a significant advancement over current severe acute respiratory syndrome coronavirus 2 testing methods.