Related Experiment Video

Updated: Jul 28, 2026

Role of Diffusion MRI Tractography in Endoscopic Endonasal Skull Base Surgery
09:53

Role of Diffusion MRI Tractography in Endoscopic Endonasal Skull Base Surgery

Published on: July 5, 2021

3.8K

Otogenic Central Skull Base Osteomyelitis With Retropharyngeal Extension: A Case Report

Regina Jacobo-Pinelli1, Jose Alberto Guerrero-Paz1, Juan Antonio Lugo-Machado1

  • 1Otolaryngology, Hospital de Especialidades No. 2 Instituto Mexicano del Seguro Social (IMSS), Ciudad Obregón, MEX.

Cureus
|April 13, 2022
PubMed

Insights

Skull base osteomyelitis (SBO) is a severe infection often diagnosed late. Antimicrobial resistance in pathogens like E. coli can complicate treatment and worsen patient prognosis.

Area of Science:

  • Infectious Diseases
  • Otolaryngology
  • Neurosurgery

Background:

  • Skull base osteomyelitis (SBO) is a serious infection, particularly in patients with comorbidities.
  • Otogenic infections can spread through skull base fissures, leading to SBO.
  • Diagnosis is often delayed due to non-specific initial symptoms like headache.

Observation:

  • A case of otogenic SBO with retropharyngeal extension is presented.
  • The patient was treated with surgical drainage and broad-spectrum antibiotics targeting ESBL-producing E. coli.
  • The infection recurred three months post-treatment.

Findings:

  • Extended-spectrum beta-lactamase (ESBL)-producing Escherichia coli can cause recurrent SBO.
  • Antimicrobial resistance poses a significant challenge in managing SBO.
  • Successful treatment may be hindered by resistant bacterial strains.

Implications:

  • Highlights the critical role of antimicrobial stewardship in managing SBO.
  • Emphasizes the need for early diagnosis and appropriate antibiotic selection.
  • Underscores the impact of antimicrobial resistance on patient outcomes in SBO.
Keywords:
esbl-positive e. colimalignant otitis externaosteomyelitisretropharyngeal abscessskull base osteomyelitis

More Related Videos

Endaural Endoscopic Atticoantrotomy Retrograde Mastoidectomy using a Constant Suction Bone-drilling Technique07:06

Endaural Endoscopic Atticoantrotomy Retrograde Mastoidectomy using a Constant Suction Bone-drilling Technique

Published on: May 23, 2021

3.9K
Surgical Treatment of an Endolymphatic Sac Tumor04:34

Surgical Treatment of an Endolymphatic Sac Tumor

Published on: May 26, 2023

860

Related Concept Videos

Bacterial Meningitis I: Introduction01:22

Bacterial Meningitis I: Introduction

Bacterial meningitis is a severe, life-threatening inflammation of the meninges, particularly the pia mater and arachnoid mater, affecting the subarachnoid space, ventricles, and cerebrospinal fluid (CSF). If untreated, it can lead to significant neurological complications or death.Causative AgentsCommon pathogens vary with age and immune status. In adults, major organisms include Streptococcus pneumoniae, Neisseria meningitidis, and Haemophilus influenzae. Streptococcus agalactiae (group B...
Brain Abscess l: Introduction01:26

Brain Abscess l: Introduction

A brain abscess is a focal, intracerebral infection characterized by a localized collection of pus within the brain parenchyma, resulting from microbial invasion and the body’s inflammatory response. It progresses through stages: early and late cerebritis, followed by early and late capsule formation, reflecting tissue destruction, immune response, and eventual encapsulation.Etiology and PathogenesisCausative organisms vary with source and host factors, often involving polymicrobial infections,...