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Wireless electrical stimulation at the nanoscale interface induces tumor vascular normalization.

Changhao Li1, Cairong Xiao1, Lizhen Zhan2

  • 1School of Material Science and Engineering, National Engineering Research Center for Tissue Restoration and Reconstruction, Metallic Materials Surface Functionalization Engineering Research Center of Guangdong Province, South China University of Technology, Guangzhou, 510641, China.

Bioactive Materials
|April 13, 2022
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Summary

This study introduces a novel wireless electrical stimulation method using piezoelectric nanoparticles to normalize tumor vasculature. This approach enhances chemotherapy effectiveness by improving drug delivery and reducing tumor growth.

Keywords:
Calcium distributionMechano-electrical conversionPiezoelectric barium titanateTumor vascular normalizationWireless electrical stimulation

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Area of Science:

  • Biomedical Engineering
  • Nanotechnology
  • Oncology

Background:

  • Pathological angiogenesis in tumors hinders chemotherapy and promotes cancer progression.
  • Existing vascular normalization methods face challenges with efficacy and resistance.
  • Endogenous bioelectricity plays a role in blood vessel formation.

Purpose of the Study:

  • To develop a wireless electrical stimulation strategy for tumor vascular normalization.
  • To investigate the mechanism of bioelectricity-induced vascular normalization.
  • To evaluate the therapeutic potential of this strategy in cancer treatment.

Main Methods:

  • Development of polarized barium titanate nanoparticles for mechano-electrical conversion.
  • Application of low-intensity pulsed ultrasound to generate wireless electrical stimulation.
  • In vitro assessment of endothelial cell behavior and signaling pathways (eNOS/NO).
  • In vivo evaluation in a tumor-bearing mouse model.

Main Results:

  • Wireless electrical stimulation inhibited endothelial cell migration and differentiation in vitro.
  • The strategy disrupted intracellular calcium ion gradients, inhibiting the eNOS/NO pathway.
  • In vivo studies showed normalized tumor vasculature, improved blood perfusion, reduced leakage, and restored oxygenation.
  • Combination therapy with doxorubicin showed 1.8 times greater efficacy than doxorubicin alone.

Conclusions:

  • Wireless electrical stimulation using piezoelectric nanoparticles offers a promising approach for tumor vascular normalization.
  • This method effectively targets tumor angiogenesis and enhances anti-tumor efficacy.
  • The strategy holds potential as a safe and effective adjuvant therapy for malignant tumors.