Related Experiment Video

Updated: Sep 27, 2025

Author Spotlight: Integrated Multi-Omics Analysis for Unveiling Multicellular Immune Signatures in Clinical Heart Attack Cohorts
08:51

Author Spotlight: Integrated Multi-Omics Analysis for Unveiling Multicellular Immune Signatures in Clinical Heart Attack Cohorts

Published on: September 20, 2024

1.5K

Association of polymorphisms in genes encoding prothrombotic and cardiovascular risk factors with disease severity in

Ivana Lapić1, Margareta Radić Antolic1, Ivana Horvat1

  • 1Department of Laboratory Diagnostics, University Hospital Center Zagreb, Zagreb, Croatia.

Journal of Medical Virology
|April 13, 2022
PubMed

Insights

Genetic variations in prothrombotic and cardiovascular risk factors are linked to COVID-19 severity. The ITGB3 PIA2 allele and Factor V (FV) H1299R combined with Factor XIII (FXIII) V34L increase severe COVID-19 risk.

Area of Science:

  • Genetics
  • Cardiovascular Medicine
  • Infectious Diseases

Background:

  • COVID-19 severity is influenced by host genetic factors.
  • Prothrombotic and cardiovascular risk factors play a role in disease pathogenesis.
  • Understanding genetic predispositions can aid in predicting COVID-19 outcomes.

Purpose of the Study:

  • To investigate the association between 16 gene polymorphisms and COVID-19 severity.
  • To identify specific genetic markers that predict a higher risk of severe disease.
  • To explore combined effects of genetic polymorphisms on COVID-19 outcomes.

Main Methods:

  • Genotyping of 16 polymorphisms in prothrombotic and cardiovascular risk genes using CVD StripAssays and real-time PCR.
  • Comparative analysis of genotype frequencies between severe (n=30) and non-severe (n=49) COVID-19 patients.
  • Statistical evaluation to determine significant associations and risk factors.

Main Results:

  • A higher frequency of the ITGB3 PIA2 allele was observed in severe COVID-19 patients (p=0.009).
  • ITGB3 polymorphism was associated with a 3.5-fold increased risk of severe COVID-19 (p=0.011).
  • Significant genotype distribution differences were found for ß-Fbg -455 G>A, and combined polymorphisms (FV H1299R/FXIII V34L, ITGB3 PIA1/A2/ITGA2B Baka/b, ACE I/D/PAI-1 4G/5G).

Conclusions:

  • ITGB3 polymorphism is an independent risk factor for severe COVID-19.
  • Homozygosity for ß-Fbg -455 G>A mutation may contribute to disease severity.
  • Combined effects of multiple genetic polymorphisms may exacerbate COVID-19 severity.

Keywords:
COVID-19cardiovascular riskgenetic polymorphismsthrombosis

More Related Videos

A Method to Study the C924T Polymorphism of the Thromboxane A2 Receptor Gene07:00

A Method to Study the C924T Polymorphism of the Thromboxane A2 Receptor Gene

Published on: April 1, 2019

10.1K
Determining the Likelihood of Variant Pathogenicity Using Amino Acid-level Signal-to-Noise Analysis of Genetic Variation07:15

Determining the Likelihood of Variant Pathogenicity Using Amino Acid-level Signal-to-Noise Analysis of Genetic Variation

Published on: January 16, 2019

11.1K

Related Concept Videos

Single Nucleotide Polymorphisms-SNPs01:05

Single Nucleotide Polymorphisms-SNPs

A single nucleotide polymorphism or SNP is a single nucleotide variation at a specific genomic position in a large population. It is the most prevalent type of sequence variation found in the human genome. Point mutations that occur in more than 1% of the population qualify as SNPs. These are present once every 1000 nucleotides on an average in the human genome. Replacement of a purine with another purine (A/G) or a pyrimidine with another pyrimidine (C/T) is known as a transition. In contrast,...
16.1K
Psychoneuroimmunology: Cardiovascular Disease01:27

Psychoneuroimmunology: Cardiovascular Disease

Psychoneuroimmunology (PNI) is a multidisciplinary field that examines how psychological factors, particularly stress, interact with the immune system and impact physical health. Research in PNI has shown that chronic or traumatic stress can disrupt both the hypothalamic-pituitary-adrenal axis and the sympathetic nervous system. These disruptions contribute to serious health conditions, including cardiovascular diseases.
A key area of focus in PNI is the relationship between stress and coronary...
89
COPD: Pathogenesis and Clinical Features01:20

COPD: Pathogenesis and Clinical Features

Chronic obstructive pulmonary disease (COPD) is a group of lung conditions that progressively worsen over time, including chronic bronchitis and emphysema. This cluster of diseases collectively leads to a gradual and irreversible decline in lung function over time.
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...
648
Coronary Artery Disease I: Introduction01:30

Coronary Artery Disease I: Introduction

Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
99
Coronary Artery Disease II: Pathophysiology01:26

Coronary Artery Disease II: Pathophysiology

Coronary Artery Disease (CAD) originates from a series of events that impair the function of coronary arteries, the blood vessels responsible for delivering oxygen-rich blood to the heart muscle. The pathophysiology of CAD is closely linked to atherosclerosis, a chronic inflammatory and lipid-driven condition affecting the vascular endothelium.1. Endothelial DamageThe process begins with damage to the vascular endothelium, which serves as a protective barrier between the blood and the vessel...
62
Acute Coronary Syndrome II: Pathophysiology and Clinical Manifestations01:19

Acute Coronary Syndrome II: Pathophysiology and Clinical Manifestations

The pathophysiology of Acute Coronary Syndrome [ACD] involves several key processes:The main underlying cause of ACD is atherosclerosis, a chronic inflammatory disease characterized by the buildup of lipid-laden plaques within the coronary arteries.As the atherosclerotic plaque grows in the coronary artery, it may become unstable due to the formation of a lipid-rich core and a thin fibrous cap. Inflammatory cells within the plaque, such as macrophages, secrete enzymes that degrade the...
64