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Methodological similarities and variations among EQ-5D-5L value set studies: a systematic review
N Poudel1, S M Fahim1, J Qian1
1Department of Health Outcomes Research and Policy, Auburn University, Auburn, AL, USA.
Journal of Medical Economics
|April 13, 2022
Summary
This study compared EQ-5D-5L valuation methods and their resulting value sets. Methodological variations did not significantly impact predicted utility scores, but further investigation is needed.
Area of Science:
- Health Economics
- Psychometrics
- Health Services Research
Background:
- The Euro-Qol 5-Dimensions 5-Levels (EQ-5D-5L) instrument is widely used for health status measurement.
- Developing accurate value sets for the EQ-5D-5L is crucial for health economic evaluations.
- Variations in valuation methods may influence the characteristics of derived EQ-5D-5L value sets.
Purpose of the Study:
- To descriptively compare valuation methods used in EQ-5D-5L value set studies.
- To compare the characteristics of the resulting EQ-5D-5L value sets.
- To examine associations between valuation method elements and EQ-5D-5L value sets.
Main Methods:
- Systematic literature search of EQ-5D-5L valuation studies (2009-2021).
- Descriptive comparison of methodological elements (sampling, modeling).
- Meta-regression analysis to assess associations between methods and value sets.
Main Results:
- 31 studies were included, showing similarities in data collection but variations in sampling, sample size, and modeling.
- Value sets differed in dimension importance and utility decrements across countries.
- No significant association found between methodological elements and mean predicted utility scores or dimension-level coefficients.
Conclusions:
- EQ-5D-5L valuation methods and value set characteristics exhibit considerable variation.
- The impact of methodological variations on value sets warrants further investigation.
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