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Chronic Salmonella Infection Induced Intestinal Fibrosis
Published on: September 22, 2019
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Inflammatory bowel disease and carcinogenesis.
Hiroko Nagao-Kitamoto1,2, Sho Kitamoto3,4, Nobuhiko Kamada5,6
1Division of Gastroenterology and Hepatology, Department of Internal Medicine, University of Michigan, 1150 W. Medical Center Drive, Ann Arbor, MI, 48109, USA. khiroko@umich.edu.
Cancer Metastasis Reviews
|April 13, 2022
Summary
Colitis-associated colorectal cancer (CAC) arises from chronic inflammation in inflammatory bowel disease (IBD). Understanding how inflammation drives genetic changes is key to preventing this deadly cancer.
Area of Science:
- Gastroenterology and Oncology
- Molecular Biology and Genetics
Background:
- Colorectal cancer (CRC) is a leading cause of cancer mortality globally.
- Colitis-associated colorectal cancer (CAC) is a distinct subtype linked to inflammatory bowel disease (IBD).
- Individuals with IBD face a 2-3 times higher risk of developing CRC, making CAC a significant concern.
Purpose of the Study:
- To investigate the mechanisms underlying CAC development.
- To explore the role of the intestinal environment, host response, and gut microbiota in CAC pathogenesis.
- To identify how chronic inflammation in IBD contributes to genomic alterations in CAC.
Main Methods:
- Analysis of animal models of chronic inflammation.
- Examination of human cohort data.
- Investigation of genomic alterations specific to CAC.
Main Results:
- Evidence suggests that changes in the intestinal environment, including dysregulated host responses and gut microbiota alterations, contribute to CAC.
- Genomic alteration patterns in CAC differ from those in sporadic CRC.
- Chronic inflammation associated with IBD is a key risk factor for CAC development.
Conclusions:
- Inflammation in IBD plays a critical role in increasing the risk of CAC.
- Further research into inflammation-induced genetic alterations and disruption of intestinal homeostasis is needed.
- Understanding these mechanisms may lead to novel therapeutic strategies for CAC prevention.
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