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In Elimination Settings, Measles Antibodies Wane After Vaccination but Not After Infection: A Systematic Review and
Shelly Bolotin1,2,3,4, Selma Osman1, Stephanie L Hughes1
1Public Health Ontario, Toronto, Ontario, Canada.
The Journal of Infectious Diseases
|April 13, 2022
Summary
Measles antibody levels decline over time after two vaccine doses, but not significantly after one dose or natural infection. This antibody waning in vaccinated individuals is crucial for measles elimination strategies.
Area of Science:
- Immunology
- Epidemiology
- Public Health
Background:
- Measles elimination requires understanding long-term immunity.
- Humoral immunity wanes over time in both infected and vaccinated individuals.
Purpose of the Study:
- To systematically review measles humoral immunity waning.
- Assess waning in previously infected or vaccinated populations.
- Inform measles elimination strategies.
Main Methods:
- Systematic review of 16,822 citations.
- Included 9 articles on wild-type measles exposure.
- Included 16 articles on vaccinated populations.
Main Results:
- Significant decline in measles geometric mean titers (GMTs) after 2 doses of measles-containing vaccine (MCV) over 20 years.
- No significant GMT decrease after 1 MCV dose or infection.
- No significant decrease in seropositivity over time for any group.
Conclusions:
- Measles antibody waning occurs in vaccinated populations.
- Consider antibody waning in measles elimination planning.
- Immunity duration impacts public health strategies.
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