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Related Concept Videos

Inflammatory Response01:28

Inflammatory Response

9.4K
An inflammatory response is a localized, nonspecific immune reaction that occurs when a tissue is injured. It is characterized by redness, swelling, heat, and pain, which are commonly called the cardinal signs and symptoms of inflammation. Inflammation can sometimes result in a loss of function.
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
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Inflammatory Response I: Vascular and Cellular01:30

Inflammatory Response I: Vascular and Cellular

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The inflammatory response is the body's defense against infection, injury, or irritation from bacteria, trauma, toxins, or heat. Inflammation helps locate and destroy pathogens and remove damaged tissue elements to heal the body. During this initial phase, fluid, blood products, and nutrients migrate to the injured area, resulting in redness, heat, swelling, ache, and loss of function. Moreover, signs of systemic inflammation include fever, increased WBC count, malaise, anorexia, nausea,...
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Inflammatory Response II: Inflammatory Exudate and Tissue Repair01:24

Inflammatory Response II: Inflammatory Exudate and Tissue Repair

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The immune system's inflammatory response destroys the invading pathogen, permitting the tissue to heal. The changes during the cellular and vascular stages allow exudate formation at the site of inflammation. The inflammatory exudate released from the wound has high protein content and a specific gravity above 1.020.
The typical wound exudate is odorless, transparent, straw-colored, thin, and watery. Exudate, however, can differ depending on the state of wound healing. Likewise, the...
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Inflammation01:38

Inflammation

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Overview
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Inflammatory Bowel Disease IV: Pharmacological Management01:29

Inflammatory Bowel Disease IV: Pharmacological Management

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Upon diagnosis, managing Inflammatory Bowel Disease (IBD) involves addressing several crucial aspects. The primary goals include resting the bowel, correcting malnutrition, and providing symptomatic relief. Resting the bowel may consist of medications to reduce inflammation and promote healing. Correcting malnutrition is essential, often requiring dietary adjustments and nutritional supplements. Symptomatic relief aims to ease pain, diarrhea, and other discomforts in IBD.
Pharmacologic...
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Inflammatory Bowel Disease II: Crohn's Disease01:30

Inflammatory Bowel Disease II: Crohn's Disease

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Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
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Updated: Sep 27, 2025

Facilitating Drug Discovery: An Automated High-content Inflammation Assay in Zebrafish
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Facilitating Drug Discovery: An Automated High-content Inflammation Assay in Zebrafish

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Nonresolving inflammation redux.

Carl Nathan1

  • 1Department of Microbiology and Immunology, Weill Cornell Medicine, New York, NY 10065, USA.

Immunity
|April 13, 2022
PubMed
Summary
This summary is machine-generated.

Persistent inflammation drives diseases like COVID-19. Emerging science reveals inflammation as a dynamic network component, influencing aging, cell death, and disease resolution.

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Area of Science:

  • Immunology and Systems Biology
  • Understanding inflammation's role in homeostasis and disease pathogenesis.

Background:

  • Nonresolving inflammation is a key factor in numerous diseases, including severe and persistent COVID-19.
  • Current understanding views inflammation not in isolation, but as an integral part of a homeostatic network involving endocrine and nervous systems.

Purpose of the Study:

  • To review emerging insights into the multifaceted nature of inflammation.
  • To explore novel concepts such as inflammatory memory, aging, and cell death.
  • To discuss inflammation-regulating factors and strategies for modulation.

Main Methods:

  • Literature review of recent advancements in inflammation research.
  • Synthesis of findings on inflammatory memory, aging, cell death, DNA, and regulatory elements.
  • Exploration of therapeutic approaches and the concept of inflammatory inequity.

Main Results:

  • Inflammation exhibits memory, contributes to aging, and involves specific cell death pathways.
  • Specialized cells and metabolites play crucial roles in regulating inflammatory processes.
  • New strategies are emerging for resolving or modulating inflammation, addressing disparities.

Conclusions:

  • Inflammation is a complex, dynamic process interconnected with other physiological systems.
  • Understanding these emerging aspects is critical for developing effective treatments for inflammatory diseases.
  • Addressing inflammatory inequity is essential for equitable health outcomes.