[THROMBOTIC COMPLICATIONS AND LATENT HYPERCOAGULATION IN PATIENTS WITH BETA-THALASSEMIA]

The aim of the work is to investigate the clinical symptoms of thrombotic complications (TC) and the tendency of patients to increased thromb-formation in patients with beta-thalassemia (β-T). Female patients with β-T aged 18-40 years were studied: 130 beta-thalassemia major (β-TM), 95 patients beta-thalassemia intermediate (β-TI), 60 patients with beta-thalassemia minor (β-Tm). In patients with βT, the frequency of occurrence of TC was studied. In patients with βT who do not have TC and splenectomy, hemostasis parameters were studied; and also the risk factors were analyzed for the development of latent hypercoagulation. Conducted questionnaire included questions about the tendency to increased thrombosis (TIT), about various clinical signs, symptoms, extended medical history data. Clinical manifestations of TC (arterial and venous thrombosis, chronic venous insufficiency) were detected in 10.0±2.6% of patients with β-TM and 14.7±3.6% of patients with βTI; TC occurred more frequently in splenectomy patients compared to non-splenectomized patients, respectively, with β-TM 15.0±4.6% and 5.7±2.8% (p≥0.05); with β-TI 22.5±6.6% and 9.1±3.9% (p≥0.05). The level of D-dimer characterizes the activity of fibrinolysis and the intensity of intravascular hemocoagulation; an increase in this marker of thrombinemia >500 ng/ml was regarded as a predisposition to LH. It was found that 37.9% of patients with β-TM and 30,4±6,8% of patients with β-TI had pre-thrombotic readiness for hemostasis ̶ latent hypercoagulability. Questionnaire indicted that in βT patients with latent hypercoagulability, D-dimer and fibrinogen levels were increased, fibrinolytic activity, activated partial thromboplastin time were reduced, and antithrombin III activity was slightly reduced. Also, questionnaire indicated the validity, significant reliability and internal consistency of the developed propensity to increased thrombosis. The results of the TIT questionnaire indicate an increased propensity for hypercoagulability in a significant proportion of non-splenectomized β-T patients.