Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Reconciling Signal-Detection Models of Criterion Learning with the Generalized Matching Law.

Computational brain & behavior·2026

Same author

LHCSR1 Functions as a Dimmer Switch for Light Harvesting.

The journal of physical chemistry letters·2026

Same author

Perinatal mAChR-mediated activation of cortical subplate neurons elicits network activity driving basket cell differentiation.

Frontiers in cellular neuroscience·2026

Same author

Upper-Body Neuromechanical Coordination Strategies During Fatiguing Sustained Dead Hangs in Climbers.

European journal of sport science·2026

Same author

Spiking neural networks provide accurate and time-efficient models for whisker stimulus classification of the awake mouse.

Frontiers in neuroscience·2026

Same author

Differences in hip, knee, and ankle joint moments during squats across load intensities, gender classes, and performance level in elite powerlifters.

Scientific reports·2026

Search research articles

Related Experiment Video

Updated: Sep 27, 2025

Flat-floored Air-lifted Platform: A New Method for Combining Behavior with Microscopy or Electrophysiology on Awake Freely Moving Rodents

Flat-floored Air-lifted Platform: A New Method for Combining Behavior with Microscopy or Electrophysiology on Awake Freely Moving Rodents

Published on: June 29, 2014

Layer- and cell-type-specific differences in neural activity in mouse barrel cortex during a whisker detection task.

Jens R Vandevelde^1,2, Jenq-Wei Yang¹, Steffen Albrecht¹

¹Institute of Physiology, University Medical Center of the Johannes Gutenberg University Mainz, Duesbergweg 6, 55128 Mainz, Germany.

Cerebral Cortex (New York, N.Y. : 1991)

|April 13, 2022

Summary

Sensory perception relies on specific neocortical layers and cell types. Layer 4 exhibits the highest sensitivity to vibrotactile stimuli, with inhibitory interneurons showing greater responsiveness than excitatory neurons.

Keywords:

barrel cortex cell types multielectrode recordings perception psychophysics

More Related Videos

Functional Magnetic Resonance Spectroscopy at 7 T in the Rat Barrel Cortex During Whisker Activation

Functional Magnetic Resonance Spectroscopy at 7 T in the Rat Barrel Cortex During Whisker Activation

Published on: February 8, 2019

Multiscale Investigations of Cortical Processing by Integrating Laminar Polytrodes and Optogenetics with Micro Electrocorticography in Rodents

Multiscale Investigations of Cortical Processing by Integrating Laminar Polytrodes and Optogenetics with Micro Electrocorticography in Rodents

Published on: May 23, 2025

Related Experiment Videos

Last Updated: Sep 27, 2025

Flat-floored Air-lifted Platform: A New Method for Combining Behavior with Microscopy or Electrophysiology on Awake Freely Moving Rodents

Flat-floored Air-lifted Platform: A New Method for Combining Behavior with Microscopy or Electrophysiology on Awake Freely Moving Rodents

Published on: June 29, 2014

Functional Magnetic Resonance Spectroscopy at 7 T in the Rat Barrel Cortex During Whisker Activation

Functional Magnetic Resonance Spectroscopy at 7 T in the Rat Barrel Cortex During Whisker Activation

Published on: February 8, 2019

Multiscale Investigations of Cortical Processing by Integrating Laminar Polytrodes and Optogenetics with Micro Electrocorticography in Rodents

Multiscale Investigations of Cortical Processing by Integrating Laminar Polytrodes and Optogenetics with Micro Electrocorticography in Rodents

Published on: May 23, 2025

Area of Science:

Neuroscience
Sensory Perception
Cortical Circuitry

Background:

Understanding neocortical contributions to sensory perception is crucial.
Identifying specific layers and cell types involved in stimulus detection remains an active research area.

Purpose of the Study:

To determine which neocortical layers and cell types are critical for sensory stimulus perception.
To investigate the neural mechanisms underlying sensory detection in the barrel cortex.

Main Methods:

Multielectrode recordings in mouse barrel cortex during a vibrotactile go/no-go task.
Analysis of multiunit and single-unit activity, including neurometric sensitivity.
Signal detection theory modeling of behavioral performance and machine learning analysis of movement.

Main Results:

Layer 4 showed the highest neurometric sensitivity to vibrotactile stimuli within 30 ms.
Significant heterogeneity in neuronal sensitivity across layers and cell types was observed.
Putative inhibitory interneurons generally exhibited higher sensitivity than excitatory neurons.
Neuron firing rate changes (increase vs. decrease) correlated with sensitivity in infragranular layers.
Reduced movement in mice was associated with better performance and increased stimulus-evoked firing rates.

Conclusions:

Layer 4 and specific neuronal populations, particularly inhibitory interneurons, play a key role in rapid sensory detection.
Neuronal sensitivity and behavioral performance are influenced by factors like motivation and movement.
The findings provide insights into the functional organization of the barrel cortex for sensory processing.