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Updated: Sep 27, 2025
In Vivo Inhibition of MicroRNA to Decrease Tumor Growth in Mice
Published on: August 23, 2019
MicroRNA-143 expression inhibits the growth and the invasion of osteosarcoma
Pei Zhang1, Jiale Zhang2, Huahong Quan3
1Department of Orthopedics, The Second Xiangya Hospital of Central South University, Changsha, 410011, Hunan, China.
Background:
Osteosarcoma (OS) is a common malignant tumor, which occurs in the metaphysis of the long diaphysis from mesenchymal tissue. Previous studies have indicated that expression of microRNA-143 (miR-143) could affect cancer cell proliferation, migration and invasion. The present research was performed to figure out whethermiR-143 expression inhibits the growth and the invasion of OS.
Methods:
We conducted a literature search in the electronic databases of Medline, Embase, Web of Science, and the Cochrane Library, SinoMed, WanFang, China national knowledge infrastructure (CNKI) until January 2022. We used Review Manager 5.3 software to conduct our research.
Results:
Twelve eligible articles were included, 5 articles were reported outcomes about mice, 11 articles were reported outcomes about human. The results of mice demonstrated that the miR-143 group had significantly better results in tumor volume, tumor weight and survival rate. The results of human demonstrated that the high level of miR-143 group had significantly better results in the 3-year, 4-year, and 5-year survival rate, lung metastasis and tumor grade.
Conclusions:
MiR-143 has potentially important value in the treatment and prognosis of OS. However, more reliable animal and clinical trials are needed before miR-143 based therapies can be transferred from animal studies to human applications.
Insights
MicroRNA-143 (miR-143) shows promise in inhibiting osteosarcoma (OS) growth and invasion. Higher miR-143 levels correlate with improved survival rates and reduced metastasis in human patients.
Area of Science:
- Oncology
- Molecular Biology
- Biomedical Research
Background:
- Osteosarcoma (OS) is a prevalent malignant bone tumor.
- MicroRNA-143 (miR-143) expression is implicated in cancer cell proliferation, migration, and invasion.
- Investigating miR-143's role in inhibiting OS growth and invasion is crucial.
Purpose of the Study:
- To evaluate the inhibitory effect of miR-143 on osteosarcoma progression.
- To assess the prognostic value of miR-143 in OS patients.
Main Methods:
- Comprehensive literature search across major electronic databases (Medline, Embase, Web of Science, Cochrane Library, SinoMed, WanFang, CNKI) until January 2022.
- Meta-analysis using Review Manager 5.3 software.
- Inclusion of 12 eligible studies with outcomes from both animal models and human patients.
Main Results:
- Animal studies indicated that miR-143 significantly improved tumor volume, tumor weight, and survival rates.
- Human studies revealed that high miR-143 levels were associated with better 3-, 4-, and 5-year survival rates.
- Elevated miR-143 expression correlated with reduced lung metastasis and improved tumor grade in human OS.
Conclusions:
- MiR-143 demonstrates significant potential in the treatment and prognosis of osteosarcoma.
- Further rigorous animal and clinical trials are necessary to translate miR-143 based therapies into human applications.
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