Expression of the proto-oncogenes C-H-ras and N-ras in early second trimester human fetal tissues

Tissues from human fetuses of 12-18 weeks gestational age were examined for expression of c-oncogenes. Dot blot hybridization showed that N-ras and C-H-ras were expressed to varying degrees in all tissues. Some of the tissues were further examined by Northern blot hybridization, and transcripts of approximately 2.2 Kb and 5.2 Kb were detected using N-ras cDNA probe. A further transcript of approximately 1.4 Kb was observed when the same blot was hybridized to C-H-ras cDNA probe. No hybridization was detected between the fetal tissues and c-K-ras, c-myc, v-erb, c-fos, c-sis and c-src.