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Surface-enhanced Resonance Raman Scattering Nanoprobe Ratiometry for Detecting Microscopic Ovarian Cancer via Folate Receptor Targeting
Published on: March 25, 2019
Aptamer Nanomaterials for Ovarian Cancer Target Theranostics
Jing Zhao1, Wenxi Tan1, Jingying Zheng1
1Department of Gynecology and Obstetrics, the Second Hospital of Jilin University, Changchun, China.
Abstract:
Ovarian cancer is among the leading causes of gynecological cancer-related mortality worldwide. Early and accurate diagnosis and an effective treatment strategy are the two primary means of improving the prognosis of patients with ovarian cancer. The development of targeted nanomaterials provides a potentially efficient strategy for ovarian cancer theranostics. Aptamer nanomaterials have emerged as promising nanoplatforms for accurate ovarian cancer diagnosis by recognizing relevant biomarkers in the serum and/or on the surface of tumor cells, as well as for effective ovarian cancer inhibition via target protein blockade on tumor cells and targeted delivery of various therapeutic agents. In this review, we summarize recent advances in aptamer nanomaterials as targeted theranostic platforms for ovarian cancer and discusses the challenges and opportunities for their clinical application. The information presented in this review represents a valuable reference for creation of a new generation of aptamer nanomaterials for use in the precise detection and treatment of ovarian cancer.
Insights
Aptamer nanomaterials offer a promising approach for ovarian cancer theranostics, enabling accurate diagnosis and effective treatment. This review highlights their potential for improving patient prognosis through targeted detection and therapy.
Area of Science:
- Biomedical Engineering
- Nanotechnology
- Oncology
Background:
- Ovarian cancer is a leading cause of gynecological cancer mortality globally.
- Improving patient prognosis relies on early diagnosis and effective treatment strategies.
- Targeted nanomaterials present a viable strategy for ovarian cancer theranostics.
Purpose of the Study:
- To review recent advancements in aptamer nanomaterials for ovarian cancer theranostics.
- To discuss the challenges and opportunities for clinical translation of these technologies.
- To provide a reference for developing next-generation aptamer nanomaterials for ovarian cancer.
Main Methods:
- Literature review of recent research on aptamer nanomaterials in ovarian cancer.
- Analysis of aptamer nanomaterial applications in diagnosis and therapy.
- Discussion of clinical challenges and future directions.
Main Results:
- Aptamer nanomaterials show promise for accurate ovarian cancer diagnosis via biomarker recognition.
- These platforms facilitate effective ovarian cancer inhibition through targeted delivery and protein blockade.
- Recent advances demonstrate their potential as theranostic platforms.
Conclusions:
- Aptamer nanomaterials are emerging as powerful tools for ovarian cancer theranostics.
- Further research and development are crucial for overcoming clinical application challenges.
- These platforms hold significant promise for precise ovarian cancer detection and treatment.
