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Updated: Sep 27, 2025

Author Spotlight: THP-1 Macrophage Response to LPS/ATP — Unveiling the Pyroptosis, Apoptosis, and Necroptosis Spectrum
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Regulation of Pyroptosis by ncRNA: A Novel Research Direction

Liyuan Gao1, Zhitao Jiang1, Yi Han1

  • 1Zhangjiagang TCM Hospital Affiliated to Nanjing University of Chinese Medicine, Suzhou, China.

Frontiers in Cell and Developmental Biology
|April 14, 2022
PubMed

Insights

Pyroptosis, a programmed cell death, involves inflammasomes and gasdermins. Non-coding RNAs (ncRNAs) play a role in pyroptosis, offering new research avenues for diseases like cancer.

Area of Science:

  • Molecular Biology
  • Cell Biology
  • Genetics

Background:

  • Pyroptosis is a programmed cell death (PCD) pathway involving inflammasomes and gasdermins.
  • Pyroptosis is implicated in inflammatory diseases and cancers, but its regulation is not fully understood.
  • Non-coding RNAs (ncRNAs), including miRNAs, lncRNAs, and circRNAs, are crucial in cellular functions.

Purpose of the Study:

  • To review the regulatory roles and functions of ncRNAs in pyroptosis.
  • To explore the association between ncRNA biology and pyroptosis hallmarks.
  • To provide new research directions for studying pyroptosis in various diseases.

Main Methods:

  • Literature review of existing research on ncRNAs and pyroptosis.
  • Analysis of the mechanisms by which ncRNAs regulate pyroptosis.
  • Synthesis of evidence linking ncRNA functions to pyroptosis pathways.

Main Results:

  • ncRNAs significantly influence the hallmarks and execution of pyroptosis.
  • Specific ncRNAs have been identified to modulate pyroptosis pathways.
  • Understanding ncRNA-mediated pyroptosis offers insights into disease mechanisms.

Conclusions:

  • ncRNAs are key regulators of pyroptosis.
  • Further investigation into ncRNA-pyroptosis interactions can reveal therapeutic targets.
  • This review highlights ncRNAs as a critical area for pyroptosis research in disease contexts.
Keywords:
gasdermininflammasomesmechanismnon-coding RNApyroptosis

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