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Updated: Sep 27, 2025
A Human Bone Marrow 3D Model to Investigate the Dynamics and Interactions Between Resident Cells in Physiological or Tumoral Contexts
Published on: December 16, 2022
Biomimetic human bone marrow tissues: models to study hematopoiesis and platforms for drug testing
Andrés García-García1, Ivan Martin1,2
1Department of Biomedicine, University Hospital Basel, University of Basel, Basel, Switzerland.
Abstract:
We propose an in vitro 3D culture system combining perfusion bioreactors, scaffolds and human primary cells to engineer fully-humanized, biomimetic and customizable bone marrow tissues. This system could serve as a model to investigate human hematopoietic stem cell niches, but also as a drug testing platform for pharmaceutical research and patient-personalized medicine.
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