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Full-Circle Cauterization of Limbal Vascular Plexus for Surgically Induced Glaucoma in Rodents
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Secondary glaucoma caused by a special type of persistent fetal vasculature

Jianing Ren1, Jiao Lyu1, Hongfei Ye1

  • 1Department of Ophthalmology, Xin Hua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Kongjiang Road, No. 1665, Shanghai, 200092, China.

International Ophthalmology
|April 14, 2022
PubMed

Insights

Surgical intervention for secondary glaucoma in infants with anterior-anterior persistent fetal vasculature (AAPFV) improved intraocular pressure and cosmetic outcomes. Most infants experienced better vision and corneal transparency post-surgery.

Area of Science:

  • Ophthalmology
  • Pediatric Ophthalmology
  • Glaucoma Research

Background:

  • Persistent fetal vasculature (PFV) can lead to secondary glaucoma in infants.
  • Anterior-anterior persistent fetal vasculature (AAPFV) is a specific subtype requiring targeted investigation.
  • Understanding clinical features and surgical outcomes is crucial for managing pediatric glaucoma.

Purpose of the Study:

  • To investigate the clinical features of infants diagnosed with glaucoma secondary to AAPFV.
  • To evaluate the surgical outcomes of infants undergoing specific procedures for AAPFV-related glaucoma.
  • To assess the efficacy of surgical interventions in improving intraocular pressure and visual function.

Main Methods:

  • Retrospective review of medical records for infants with AAPFV and secondary glaucoma.
  • Surgical procedures included synechialysis, pupilloplasty, lensectomy, and limbal vitrectomy.
  • Minimum 6-month postoperative follow-up was required for inclusion.

Main Results:

  • Eleven infants were included, with a median age of 4 months at surgery.
  • All patients achieved normal anterior chamber, improved pupillary configuration, and controlled intraocular pressure (IOP), except one case of phthisis bulbi.
  • 81.8% of eyes showed improved corneal transparency, and 6/9 patients improved visual acuity from no light perception to light perception.

Conclusions:

  • AAPFV is a distinct PFV type associated with secondary glaucoma in infants.
  • Surgical treatment for AAPFV-related glaucoma can lead to improved vision, IOP control, and cosmetic results.
  • Early surgical intervention may be beneficial for managing this condition.
Abstract

Keywords:
Anterior-anterior persistent fetal vasculatureCongenital pupillary-iris-lens membraneLimbal approachSecondary glaucomaSurgery management

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