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Updated: Sep 27, 2025

Preparation and Use of Carbonyl-decorated Carbenes in the Activation of White Phosphorus
Published on: October 3, 2014
Selective Labeling of Peptides with o-Carboranes via Manganese(I)-Catalyzed C-H Activation
Becky Bongsuiru Jei1,2, Long Yang1,2, Lutz Ackermann1,2
1Institut für Organische und Biomolekulare Chemie, Georg-August-Universität Göttingen, Tamannstraße 2, 37077, Göttingen, Germany.
Abstract:
A robust method for the selective labeling of peptides via manganese(I) catalysis was devised to achieve the C-2 alkenylation of tryptophan containing peptides with 1-ethynyl-o-carboranes. The manganese-catalyzed C-H activation was accomplished with high catalytic efficiency, and featured low toxicity, high functional group tolerance and excellent E-stereoselectivity. This approach unravels a promising tool for the assembly of o-carborane with structurally complex peptides of relevance to applications in boron neutron capture therapy.
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