[Optimal oxygen administration-new evidence from treating COVID-19?]

Area of Science:

• Physiology
• Cellular Biology
• Medical Science

Background:

• Oxygen is vital for human cell energy production and survival.
• The body employs compensatory mechanisms to maintain oxygen delivery during disruptions.
• Failure to compensate for oxygen deficit risks cellular and organ system dysfunction.

Purpose of the Study:

• To review fundamental physiological mechanisms of oxygen delivery.
• To outline methods for detecting insufficient oxygen (hypoxia).
• To present current guidelines and research on target oxygen levels.

Main Methods:

• Literature review of physiological mechanisms.
• Analysis of diagnostic approaches for oxygenation disorders.
• Synthesis of current clinical guidelines and research findings.

Main Results:

• Established physiological pathways of oxygen transport and utilization.
• Various methods exist for detecting oxygen insufficiency.
• Existing oxygen target values remain the standard of care.

Conclusions:

• Understanding oxygen delivery is key to managing hypoxemia.
• Clinical decisions on oxygen therapy require careful assessment of compensatory capacity.
• Despite recent attention, no new oxygen targets have emerged from the COVID-19 pandemic.