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Related Concept Videos

Teratogenicity01:07

Teratogenicity

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The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...
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Does Resveratrol Prevent Sevoflurane Toxicity in Newborn Rats?

Ayşenur Sümer Coşkun1, Hatice Aslı Bedel2, Mustafa Munzuroğlu3

  • 1Anesthesiology Department, Antalya Kepez State Hospital, Antalya, Turkey.

Journal of Medicinal Food
|April 14, 2022
PubMed
Summary

Sevoflurane anesthesia harms newborn rat learning and memory. Resveratrol pretreatment, particularly at 50 mg/kg, reversed these neurotoxic effects and may involve the brain-derived neurotrophic factor (BDNF) pathway.

Keywords:
BDNFlearning and memoryneurotoxicityresveratrolsevoflurane

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Area of Science:

  • Neuroscience
  • Pharmacology
  • Developmental Biology

Background:

  • Inhalation anesthetics like sevoflurane can induce neurotoxicity and neurodevelopmental disorders.
  • The brain-derived neurotrophic factor (BDNF) pathway is crucial for neuronal survival and function.

Purpose of the Study:

  • To investigate the neuroprotective effects of resveratrol against sevoflurane-induced neurotoxicity in newborn rats.
  • To explore the role of the BDNF pathway in sevoflurane's neurotoxic effects and resveratrol's potential intervention.

Main Methods:

  • Newborn rats were exposed to sevoflurane anesthesia with or without resveratrol pretreatment (25 or 50 mg/kg).
  • Cognitive functions were assessed using the Morris Water Maze and Open Field tests.
  • Hippocampal BDNF levels were quantified via Western blot analysis.

Main Results:

  • Sevoflurane exposure significantly impaired learning and memory in the Morris Water Maze test.
  • Resveratrol pretreatment (50 mg/kg) reversed sevoflurane-induced cognitive deficits.
  • Sevoflurane decreased hippocampal BDNF levels, an effect ameliorated by 50 mg/kg resveratrol.

Conclusions:

  • Sevoflurane anesthesia negatively impacts learning and memory in developing rats.
  • Resveratrol demonstrates neuroprotective potential against sevoflurane-induced neurotoxicity.
  • The BDNF pathway is implicated in the beneficial effects of resveratrol in this model.