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Updated: Sep 27, 2025
Author Spotlight: Scalable Drug Screening Protocol for Efficient Discovery of M. abscessus Treatments
Published on: October 25, 2024
In Vitro Bedaquiline and Clofazimine Susceptibility Testing in Mycobacterium abscessus
Bettina Schulthess1,2, Fatma Nur Akdoğan Kittana1, Rico Hömke1,2
1Institute of Medical Microbiology, University of Zurichgrid.7400.3, Zurich, Switzerland.
Abstract:
Bedaquiline and clofazimine are increasingly used to treat infections with Mycobacterium abscessus. We determined distributions of MICs by broth microdilution for bedaquiline and clofazimine for 61 M. abscessus clinical isolates using different media and incubation times. We show that incubation time and growth media critically influence the MIC. Our data will aid in defining future clinical breakpoints for in vitro susceptibility testing for bedaquiline and clofazimine in M. abscessus.
