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COVID-19: The question of genetic diversity and therapeutic intervention approaches

David Livingstone Alves Figueiredo1,2,3, João Paulo Bianchi Ximenez4,3, Fábio Rodrigues Ferreira Seiva5,3

  • 1Universidade Estadual do Centro-Oeste do Paraná (UNICENTRO), Departamento de Medicina, Guarapuava, PR, Brazil.

Genetics and Molecular Biology
|April 14, 2022
PubMed

Insights

This review examines strategies to control Coronavirus disease 2019 (COVID-19), including vaccines and therapeutics. It also addresses challenges posed by genetic variability in controlling the SARS-CoV-2 pandemic.

Area of Science:

  • * Infectious Diseases
  • * Virology
  • * Immunology

Background:

  • * Coronavirus disease 2019 (COVID-19), caused by SARS-CoV-2, is a global pandemic with significant mortality.
  • * The pandemic necessitated rapid development of vaccines, therapeutics, and drug repurposing strategies.
  • * Understanding viral and host genetic factors is crucial for effective pandemic control.

Purpose of the Study:

  • * To review current strategies for controlling COVID-19.
  • * To assess the efficacy of vaccines, novel drugs, and repurposed medications.
  • * To identify limitations of therapeutic approaches due to genetic variability.

Main Methods:

  • * Comprehensive literature review of scientific publications on COVID-19.
  • * Analysis of vaccine development and clinical trial data.
  • * Evaluation of therapeutic strategies targeting viral replication and host immune response.

Main Results:

  • * Multiple COVID-19 vaccine candidates have received authorization, with others in development.
  • * Therapeutic strategies focus on inhibiting viral entry/replication and modulating immune responses.
  • * Nanotechnology shows promise for enhancing drug efficacy against SARS-CoV-2.
  • * Human and viral genetic variability present challenges for some control approaches.

Conclusions:

  • * A multifaceted approach combining vaccines and therapeutics is essential for managing COVID-19.
  • * Ongoing research is vital to overcome challenges posed by genetic variability.
  • * Continued development and evaluation of novel and repurposed treatments are necessary.

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