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Related Concept Videos

Control Systems01:10

Control Systems

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Control systems are everywhere in contemporary society, influencing diverse applications from aerospace to automated manufacturing. These systems can be found naturally within biological processes, such as blood sugar regulation and heart rate adjustment in response to stress, as well as in man-made systems like elevators and automated vehicles. A control system is essentially a network of subsystems and processes that collaboratively convert specific inputs into desired outputs.
At the heart...
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Quality Control01:05

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Quality control is one of the three cyclical quality assurance activities that help keep a system under statistical control. Typical quality control activities include creating quality control charts, conducting proficiency testing, and documenting and archiving results.
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Locus of Control01:26

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Locus of control describes how individuals perceive the causes of events in their lives, influencing motivation and well-being. Introduced by Julian Rotter in 1954, it is categorized into internal and external locus of control.Internal Locus of ControlIndividuals with an internal locus of control believe their actions determine outcomes, fostering responsibility, self-efficacy, and motivation. For example, an employee may attribute career success to hard work. Research links this mindset to...
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Robbers Cave04:49

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During the 1950s, the landmark Robbers Cave experiment demonstrated that when groups must compete with one another, intergroup conflict, hostility, and even violence may result. At the Oklahoman summer camp, two troops of boys—termed the Rattlers and the Eagles—took part in a week-long tournament. During this time, their negativity culminated in derogatory name-calling, fistfights, and even vandalism and destruction of property. However, this work also revealed that such tension...
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Control of Power Flow01:30

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There are several methods to control power flow in power systems:
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Self-Discrepancy Theory02:45

Self-Discrepancy Theory

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One influential perspective on what motivates people's behavior is detailed in Tory Higgin's self-discrepancy theory (Higgins, 1987). He proposed that people hold disagreeing internal representations of themselves that lead to different emotional states.  
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The quest for control.

Nisha Philip1

  • 1Institute of Immunology and Infection Research, School of Biological Sciences, University of Edinburgh, Edinburgh EH9 3FL, UK.

Cell Host & Microbe
|April 14, 2022
PubMed
Summary

Researchers developed a rapid protein degradation tool for the malaria parasite Plasmodium berghei. This commentary reviews the technology

Area of Science:

  • Malaria parasite biology
  • Molecular parasitology
  • Drug discovery tools

Background:

  • The malaria parasite Plasmodium berghei presents unique challenges for genetic manipulation.
  • Targeted protein degradation is a crucial tool for understanding gene function in pathogens.
  • Previous methods for manipulating Plasmodium berghei were time-consuming.

Purpose of the Study:

  • To provide historical context and scientific rationale for developing a rapid protein degradation tool.
  • To discuss the technical advancements and key milestones in creating this technology.
  • To outline future research directions and applications of the tool.

Main Methods:

  • Development of a conditional knockout system for essential genes.
  • Utilizing rapid protein degradation strategies within the parasite.

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  • Genetic engineering of Plasmodium berghei for inducible protein depletion.

    • Main Results:

    • Successful establishment of a system for rapid, inducible protein depletion in Plasmodium berghei.
    • Demonstration of the tool's efficacy in studying essential gene function.
    • Validation of the technology for high-throughput screening and genetic analysis.

    Conclusions:

    • The rapid protein degradation tool significantly advances research capabilities in Plasmodium berghei.
    • This technology facilitates faster investigation of parasite biology and potential drug targets.
    • Future applications include accelerated drug development and a deeper understanding of malaria pathogenesis.