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Nanoarchitectured two-dimensional layered double hydroxides-based nanocomposites for biomedical applications
1Institute of Biomaterials and Tissue Engineering, Huaqiao University, Xiamen 361021, PR China; College of Chemical Engineering, Huaqiao University, Xiamen 361021, PR China; Fujian Provincial Key Laboratory of Biochemical Technology (Huaqiao University), Xiamen 361021, PR China.
Advanced Drug Delivery Reviews
|April 14, 2022
Summary
Layered double hydroxides (LDHs) show promise in biomedicine but face stability and targeting issues. Engineering LDH nanocomposites enhances their performance for applications like drug delivery and bioimaging.
Area of Science:
- Materials Science
- Nanotechnology
- Biomedical Engineering
Background:
- Pristine layered double hydroxides (LDHs), also known as 2D hydrotalcite clays, possess unique physicochemical and morphological properties.
- However, LDHs exhibit limitations in biomedical applications, including poor thermal/chemical stability, acid degradation, and lack of targeting, hindering clinical translation.
Purpose of the Study:
- To review the limitations of pristine LDHs and discuss engineering strategies for LDH-based nanocomposites.
- To evaluate the performance of diverse LDH nanocomposites in various biomedical applications.
- To highlight the impact of supramolecular assembly properties on nanocomposite efficacy.
Main Methods:
- Review of existing literature on LDH chemistry, limitations, and modification strategies.
- Analysis of diverse LDH nanocomposite fabrication techniques (surface coating, impregnation, core-shell).
- Evaluation of performance data for LDH nanocomposites in drug delivery, bioimaging, biosensing, tissue engineering, DNA extraction, and photoluminescence.
Main Results:
- Engineering strategies effectively address the limitations of pristine LDHs, leading to advanced nanocomposite architectures.
- LDH nanocomposites demonstrate significant efficacy across a spectrum of biomedical applications.
- The properties of integrated supramolecular assemblies critically influence the performance of LDH-based systems.
Conclusions:
- LDH nanocomposites offer a viable path to overcome the challenges associated with pristine LDHs for medical use.
- Further research and development are needed to optimize scale-up processing and clinical applicability.
- Lessons learned from current strategies provide a roadmap for future advancements in LDH-based nanomedicine.
