Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Standardized extracts, trees.

L Belin

    Clinical Reviews in Allergy
    |November 1, 1986
    PubMed
    Summary
    This summary is machine-generated.

    Tree pollen allergies are common in spring, often worsened by cross-reactivity. Standardized birch pollen extracts (IS) improve diagnosis and treatment, with promising new oral administration trials.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Prognosis of glioblastoma patients improves significantly over time interrogating historical controls.

    European journal of cancer (Oxford, England : 1990)·2024
    Same author

    Clinical features and outcomes of patients with pancreatic cancer requiring unplanned medical ICU admission: A retrospective multicenter study.

    Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·2023
    Same author

    TIRADS score is of limited clinical value for risk stratification of indeterminate cytological results.

    European journal of endocrinology·2018
    Same author

    Evaluation at 3 years of concurrent bevacizumab and radiotherapy for breast cancer: Results of a prospective study.

    Cancer radiotherapie : journal de la Societe francaise de radiotherapie oncologique·2018
    Same author

    Second malignancies after permanent implant prostate cancer brachytherapy: A single-institution study of 675 patients treated between 1999 and 2003.

    Cancer radiotherapie : journal de la Societe francaise de radiotherapie oncologique·2017
    Same author

    Randomized phase II trial comparing molecularly targeted therapy based on tumor molecular profiling versus conventional therapy in patients with refractory cancer: cross-over analysis from the SHIVA trial.

    Annals of oncology : official journal of the European Society for Medical Oncology·2016
    Same journal

    Immunosuppressive agents and asthma.

    Clinical reviews in allergy·1994
    Same journal

    Leukotriene and thromboxane antagonists.

    Clinical reviews in allergy·1994
    Same journal

    Novel approaches in immunotherapy.

    Clinical reviews in allergy·1994
    Same journal

    Potassium channel openers and asthma.

    Clinical reviews in allergy·1994
    Same journal

    The legal liability of the Institutional Review Board.

    Clinical reviews in allergy·1994
    Same journal

    New perspectives in information retrieval.

    Clinical reviews in allergy·1994
    See all related articles

    Area of Science:

    • Immunology
    • Allergology
    • Biochemistry

    Background:

    • Tree pollen sensitization, particularly from Betulaceae (birches), is a significant cause of spring allergies, comparable to or exceeding grass pollen allergies.
    • Prolonged symptoms result from cross-reactivity between tree species and multiple pollen sensitivities.
    • There is a critical need for standardized pollen extracts to enhance diagnostic accuracy and therapeutic effectiveness.

    Purpose of the Study:

    • To highlight the development and importance of standardized birch pollen extracts for allergy diagnosis and treatment.
    • To discuss the current status of allergen characterization and standardization within the Betulaceae family.
    • To review the progress and potential of clinical trials using standardized tree pollen extracts, including novel administration routes.

    Related Experiment Videos

    Main Methods:

    • Utilizing immunochemical data and reproducible quantitative/qualitative methods to characterize birch pollen allergens.
    • Establishing an International Standard (IS) through international collaboration, accepted by the IUIS Subcommittee on Allergen Standardization.
    • Employing RAST inhibition assays to determine total biologic activity of standardized extracts.

    Main Results:

    • An International Standard (IS) for birch pollen extract has been established, defined by major and intermediate allergens and total biologic activity.
    • Reproducible laboratory methods for allergen measurement are available globally.
    • Early clinical trials with standardized tree pollen extracts, especially those using oral administration, show promising results.

    Conclusions:

    • Standardized birch pollen extracts provide a crucial benchmark for allergy diagnostics and immunotherapy.
    • Further research is needed to establish in vivo biologic activity declarations.
    • Clinical investigations, particularly with oral immunotherapy, represent a significant advancement in managing tree pollen allergies.