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Author Spotlight: Unveiling the Connection Between Sleep Disorders and Cognitive Symptoms in Depression
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Depressive symptoms predict memory decline in Essential Tremor.

Jennifer R Miller1, Silvia Chapman2, Daniella Iglesias Hernandez3

  • 1Ferkauf Graduate School of Psychology, Yeshiva University, Bronx, NY, USA.

Parkinsonism & Related Disorders
|April 14, 2022
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Summary

Depressive symptoms predict memory decline in older adults with Essential Tremor (ET). Those with 5 or more symptoms showed faster memory loss over 36 months, highlighting a link between mood and cognition in ET patients.

Keywords:
CognitionDepressionEssential tremorNeurodegeneration

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Area of Science:

  • Neurology
  • Geriatrics
  • Psychiatry

Background:

  • Essential Tremor (ET) is a common movement disorder with motor, cognitive, and psychiatric symptoms.
  • Depressed mood in ET is often considered a psychological response but may predict cognitive decline.
  • Emerging evidence suggests depressive symptoms predict cognitive decline in various populations.

Purpose of the Study:

  • To investigate if depressive symptoms predict cognitive decline in older adults with ET.
  • To assess the impact of depressive symptoms on global cognition, memory, and executive functioning.

Main Methods:

  • 125 cognitively normal ET participants underwent 3 in-person assessments over 36 months.
  • Depressive symptoms were measured using the Geriatric Depression Scale (GDS).
  • Cognitive function was assessed via comprehensive neuropsychological evaluations; generalized linear regression models were used.

Main Results:

  • Depressive symptoms (GDS ≥ 5) did not predict decline in global cognition or executive functioning.
  • Participants with 5 or more depressive symptoms exhibited significantly faster memory decline.
  • This association remained significant in both unadjusted and adjusted models.

Conclusions:

  • The presence of 5 or more depressive symptoms predicts mildly faster memory decline in cognitively normal older adults with ET over 36 months.
  • Findings suggest a potential link between depressive symptoms and memory decline in ET.
  • Further research into mechanisms and clinical implications is warranted.