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Association between Depression and Clinical Outcomes following Percutaneous Coronary Intervention: A Meta-Analysis

Yifan Zhang1, You Zhai2, Bohan Niu3

  • 1First Clinical Medical College, Henan University of Chinese Medicine, Zhengzhou, China.

Psychopathology
|April 14, 2022
PubMed

Insights

Depression increases the risk of major adverse cardiac events and all-cause mortality in patients undergoing percutaneous coronary intervention (PCI). Mental health support is crucial for improving outcomes in coronary heart disease (CHD) patients post-PCI.

Area of Science:

  • Cardiology
  • Psychiatry
  • Clinical Research

Background:

  • Conflicting evidence exists regarding the association between depression and outcomes after percutaneous coronary intervention (PCI) in coronary heart disease (CHD).
  • This meta-analysis aims to clarify the relationship between depression and clinical outcomes in patients following PCI.

Approach:

  • A comprehensive literature search was conducted across major databases (PubMed, Web of Science, EMBASE, Medline, Google Scholar) for studies published before July 2021.
  • Hazard ratios (HRs) and 95% confidence intervals (CIs) were calculated using random or fixed effects models to determine pooled effect sizes.
  • Heterogeneity between studies was assessed using the Q test and I2 statistic.

Key Points:

  • Depression is linked to a significantly higher risk of major adverse cardiac events (MACE) post-PCI (HR = 1.89, 95% CI: 1.33-2.68).
  • A higher risk of all-cause mortality was observed in patients with depression after PCI (HR = 1.71, 95% CI: 1.43-2.05).
  • No significant association was found between depression and the risk of repeat revascularization post-PCI (HR = 2.10, 95% CI: 0.96-4.58).

Conclusions:

  • Depression is associated with adverse clinical outcomes, including MACE and mortality, in coronary heart disease patients following PCI.
  • Routine mental health screening and psychological interventions are recommended for CHD patients undergoing PCI to improve prognosis.
Abstract

Keywords:
Clinical outcomesCoronary heart diseaseDepressionMeta-analysisPercutaneous coronary intervention

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