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Incomplete Dominance

Incomplete Dominance

Gregor Mendel's work (1822 - 1884) was primarily focused on pea plants. Through his initial experiments, he determined that every gene in a diploid cell has two variants called alleles inherited from each parent. He suggested that amongst these two alleles, one allele is dominant in character and the other recessive. The combination of alleles determines the phenotype of a gene in an organism.

Position-effect Variegation

Position-effect Variegation

In 1928, a German botanist Emil Heitz observed the moss nuclei with a DNA binding dye. He observed that while some chromatin regions decondense and spread out in the interphase nucleus, others do not. He termed them euchromatin and heterochromatin, respectively. He proposed that the heterochromatin regions reflect a functionally inactive state of the genome. It was later confirmed that heterochromatin is transcriptionally repressed, and euchromatin is transcriptionally active chromatin.

Law of Segregation

Law of Segregation

When crossing pea plants, Mendel noticed that one of the parental traits would sometimes disappear in the first generation of offspring, called the F1 generation, and could reappear in the next generation (F2). He concluded that one of the traits must be dominant over the other, thereby causing masking of one trait in the F1 generation. When he crossed the F1 plants, he found that 75% of the offspring in the F2 generation had the dominant phenotype, while 25% had the recessive phenotype.

The Ratio of X Chromosome to Autosomes

The Ratio of X Chromosome to Autosomes

In most organisms, sex is determined by the ratio of X and Y chromosomes. However, in some organisms, such as Drosophila and C.elegans, sex is determined by the ratio of the number of X chromosomes to the number of sets of autosomes. The Y chromosome in Drosophila is active but does not determine sex. It contains genes responsible for the production of sperms in adult flies.
Normal male Drosophila has a ratio of one X chromosome to two sets of autosomes. In contrast, normal female...

Dosage Compensation

Dosage Compensation

In animals, gender is determined by the number and type of sex chromosome. For example, human females have two X chromosomes, and males have one X and one Y chromosome, whereas C.elegans with one X chromosome is a male, and the one with two X chromosomes is a hermaphrodite.
In addition to sexual development, the X chromosome has genes involved in autosomal functions such as brain development and the immune system. Therefore, males and females with distinct numbers of X chromosomes will...

Multiple Allele Traits

Multiple Allele Traits

The Concept of Multiple Allelism

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Related Experiment Video

Updated: Sep 27, 2025

Microbiota Analysis Using Two-step PCR and Next-generation 16S rRNA Gene Sequencing

Microbiota Analysis Using Two-step PCR and Next-generation 16S rRNA Gene Sequencing

Published on: October 15, 2019

Serodominance Profile in a Dust Mite Complex Region.

Raquel López-Rodríguez¹, Manuel Jorge Rial¹, Ignacio Esteban-Gorgojo²

¹Allergy Department, Complexo Hospitalario Universitario A Coruña, A Coruña, Spain.

International Archives of Allergy and Immunology

|April 14, 2022

Summary

This study reveals specific molecular sensitization profiles in house dust mite (HDM) and storage mite allergy patients. Understanding these profiles aids in precise diagnosis and optimal management of mite allergies.

Keywords:

Component resolved diagnosis Dermatophagoides pteronyssinus House dust mites Lepidoglyphus destructor Molecular diagnosis

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Published on: August 22, 2013

Area of Science:

Allergy and Immunology
Molecular Biology
Environmental Health

Background:

High environmental exposure to house dust mites (HDM) and storage mites necessitates understanding sensitization profiles.
Mite allergy is a significant health concern, particularly in regions with high exposure levels.

Purpose of the Study:

To describe the molecular sensitization profile of mite allergy.
To correlate molecular allergen sensitization with clinical manifestations in patients exposed to HDM and storage mites.

Main Methods:

Skin prick tests were conducted using standardized mite extracts.
A commercial molecular allergen panel was used to assess specific IgE.
Clinical parameters were correlated with molecular sensitization data in Galician patients.

Main Results:

High sensitization rates were observed for Dermatophagoides pteronyssinus (Dpt), Dermatophagoides farinae (Dfar), Lepidoglyphus destructor (Ldt), Tyrophagus putrescentiae (Tput), and Blomia tropicalis (Blot).
Specific IgE to Der p 1, Der p 2, and Der p 23 were prevalent.
Sensitization to Der f 2, Der p 2, and Der p 23 increased the relative risk for atopic dermatitis (AD), while Der p 10 decreased it.

Conclusions:

Evaluating IgE to a comprehensive allergen panel aids in differentiating serological reactivity and guiding optimal patient management.
Component-resolved diagnostics and further research into mite allergen clinical relevance are crucial for accurate diagnosis and effective immunotherapy.