A conserved module regulates receptor kinase signalling in immunity and development.
Thomas A DeFalco1,2, Pauline Anne3, Sean R James4
1Institute of Plant and Microbial Biology and Zürich-Basel Plant Science Center, University of Zürich, Zurich, Switzerland.
Nature Plants
|April 15, 2022
Summary
Plant immune and developmental signaling pathways share a common regulatory module involving type-2C protein phosphatases. This mechanism dampens signaling without ligand and promotes it upon activation, revealing a conserved circuit for receptor kinase signaling.
Area of Science:
- Plant biology
- Molecular signaling
- Cellular processes
Background:
- Cell-surface receptor signaling is crucial for animal and plant development and immunity.
- Mechanisms regulating plant receptor signaling for cellular responses are not well understood.
Purpose of the Study:
- To investigate the regulatory mechanisms of plant receptor signaling in immunity and development.
- To identify shared regulatory modules between pathogen-associated molecular patterns (PAMPs) and CLAVATA3/EMBRYO SURROUNDING REGION-RELATED peptides (CLEp) signaling.
Main Methods:
- Analysis of signaling pathways involving plant receptors.
- Investigating the role of type-2C protein phosphatases in PAMP and CLEp signaling.
- Studying the phosphorylation events mediated by cytosolic kinases.
Main Results:
- A similar regulatory module is utilized by plant PAMP and CLEp receptors.
- Type-2C protein phosphatases dampen receptor signaling in the absence of ligand.
- Receptor activation leads to phosphorylation of phosphatases by divergent kinases, promoting signaling.
Conclusions:
- A conserved regulatory circuit involving type-2C protein phosphatases is shared between plant immune and developmental receptor signaling.
- This finding has broad implications for understanding plant receptor kinase-mediated signaling.
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