Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Cyclodextrins in drug carrier systems.

K Uekama, M Otagiri

    Critical Reviews in Therapeutic Drug Carrier Systems
    |January 1, 1987
    PubMed
    Summary

    Cyclodextrins form inclusion complexes with drugs, enhancing their properties for biomedical applications. Research shows these complexes improve drug delivery, stability, and bioavailability, overcoming previous application barriers.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Establishment of a model of acetaminophen-induced hepatotoxicity in different weekly-aged ICR mice.

    Laboratory animals·2015
    Same author

    Arginine 485 of human serum albumin interacts with the benzophenone moiety of ketoprofen in the binding pocket of subdomain III A and III B.

    Die Pharmazie·2012
    Same author

    Potential use of folate-polyethylene glycol (PEG)-appended dendrimer (G3) conjugate with α-cyclodextrin as DNA carriers to tumor cells.

    Cancer gene therapy·2012
    Same author

    Genogroup distribution of F-specific coliphages in wastewater and river water in the Kofu basin in Japan.

    Letters in applied microbiology·2012
    Same author

    Antioxidative effect of albumin on amyloid fibril formation in transthyretin-related amyloidosis.

    Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis·2011
    Same author

    Enhancement of dissolution and bioavailability of flurbiprofen by low molecular weight chitosans.

    Die Pharmazie·2010

    Area of Science:

    • Biomedical science
    • Pharmaceutical chemistry
    • Drug delivery systems

    Background:

    • Cyclodextrins are known for forming inclusion complexes with drug molecules.
    • Extensive research and industrial production have removed barriers to natural cyclodextrins' biomedical use.
    • Cyclodextrin derivatives and polymers offer enhanced inclusion abilities compared to parent cyclodextrins.

    Purpose of the Study:

    • To review the application of cyclodextrins in improving drug properties.
    • To explore the potential of cyclodextrin inclusion complexes in drug formulation and delivery.
    • To highlight challenges and future directions for cyclodextrin-based drug carrier systems.

    Main Methods:

    • Review of existing literature on cyclodextrin inclusion complexation.
    • Analysis of studies demonstrating improved drug solubility, dissolution, release rates, stability, and bioavailability.
    • Examination of research on cyclodextrin derivatives and polymers for drug delivery.

    Main Results:

    • Natural cyclodextrins and their derivatives successfully improve various drug properties.
    • Inclusion complexation enhances drug activity, selective transfer, and reduces side effects.
    • Drug-cyclodextrin complexes dissociate in vivo, providing fast and uniform drug release.

    Conclusions:

    • Cyclodextrin inclusion phenomena enable rational drug formulation design.
    • The stability constant of inclusion complexes is crucial for biomedical applications, especially parenteral.
    • Combining molecular encapsulation with other carrier systems is a promising strategy for future drug delivery systems.

    Related Experiment Videos