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Measurement of Factor V Activity in Human Plasma Using a Microplate Coagulation Assay
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Multi-factorial Mechanism Behind COVID-19 Related Thrombosis

Elshazali Widaa Ali1,2, Ibrahim Khedir Ibrahim2

  • 1Department of Medical Laboratory Sciences, College of Applied Medical Science, University of Bisha, Bisha, Saudi Arabia.

Medical Archives (Sarajevo, Bosnia and Herzegovina)
|April 15, 2022
PubMed

Insights

COVID-19 patients face a high risk of thrombosis due to multifactorial causes. Key factors include inflammation, endothelial damage, and antiphospholipid antibodies, contributing to severe outcomes like pulmonary embolism.

Area of Science:

  • Medical Science
  • Virology
  • Hematology

Background:

  • Thrombosis is a significant complication of COVID-19, affecting approximately one-third of patients.
  • Pulmonary embolism is the most common thrombotic event observed in COVID-19 cases.

Purpose of the Study:

  • To review published data on COVID-19 related thrombosis.
  • To summarize predisposing factors and mechanisms of thrombosis in COVID-19.

Main Methods:

  • Systematic review of existing literature on COVID-19 and thrombosis.
  • Analysis of predisposing factors and etiological mechanisms.

Main Results:

  • COVID-19 thrombosis is multifactorial, involving inflammation, hyperviscosity, and endothelial damage.
  • SARS-CoV-2 infection can induce antiphospholipid antibodies, increasing hypercoagulability.
  • Thrombophilic mutations (e.g., Factor V Leiden) may contribute to thrombosis and disease severity, though research is conflicting.

Conclusions:

  • The multifactorial nature of COVID-19 thrombosis involves endothelial damage, antiphospholipid antibodies, inflammation, hyperviscosity, and thrombophilic mutations.
  • These factors collectively predispose COVID-19 patients to thrombotic events.
Abstract

Keywords:
Antiphospholipid antibodiesCOVID-19HyperviscosityInflammationThrombosisthrombophilia

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