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Updated: Sep 27, 2025

Magnetic Resonance Imaging of Multiple Sclerosis at 7.0 Tesla
08:51

Magnetic Resonance Imaging of Multiple Sclerosis at 7.0 Tesla

Published on: February 19, 2021

9.2K

Incidence of Developmental Venous Anomalies in Patients With Multiple Sclerosis: A 3 Tesla MRI Study

Marton Magyar1, Thomas Gattringer1,2, Christian Enzinger1,2

  • 1Department of Radiology (Division of Neuroradiology, Vascular and Interventional Radiology), Medical University of Graz, Graz, Austria.

Frontiers in Neurology
|April 15, 2022
PubMed
Abstract

Insights

Developmental venous anomalies (DVA) occur with similar frequency in multiple sclerosis (MS) patients and controls. However, DVA size was smaller in MS patients compared to controls, suggesting a potential venous system association.

Area of Science:

  • Neuroimaging
  • Vascular Neurology
  • Neuroimmunology

Background:

  • The venous system's role in multiple sclerosis (MS) is increasingly recognized.
  • The association between MS and developmental venous anomalies (DVA) requires further investigation.
  • Understanding DVA in different MS phenotypes is crucial.

Purpose of the Study:

  • To determine the frequency and extent of DVA in patients with clinically isolated syndrome (CIS) and MS.
  • To compare DVA presence and characteristics between MS phenotypes and a control group.
  • To explore potential links between DVA and the venous system in MS.

Main Methods:

  • Analysis of contrast-enhanced T1-weighted MR scans from 431 patients (CIS and MS) and 162 controls.
  • Identification and measurement of DVA and draining vein size.
  • Comparison of DVA frequency and size across different MS phenotypes and controls.

Main Results:

  • DVA was found in 8.8% of MS/CIS patients and 6.8% of controls (p=0.4).
  • DVA frequency was highest in CIS (14.8%) and lowest in progressive MS (4.0%).
  • Mean DVA and draining vein size was significantly smaller in MS patients than controls (p<0.05).

Conclusions:

  • DVA frequency in MS patients is comparable to that in the general population.
  • The reduced size of DVA in MS patients warrants further investigation.
  • Longitudinal studies with larger cohorts are needed to understand DVA changes over time in MS.
Keywords:
central nervous systemclinically isolated syndrome (CIS)developmental venous anomaly (DVA)magnetic resonance imagingmultiple sclerosis

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