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Ferroptosis as a Novel Therapeutic Target for Diabetes and Its Complications

Xi-Ding Yang1,2, Yong-Yu Yang1,3

  • 1Department of Pharmacy, The Second Xiangya Hospital of Central South University, Changsha, China.

Frontiers in Endocrinology
|April 15, 2022
PubMed

Insights

Ferroptosis, a cell death form, is increasingly linked to diabetes and its complications. Targeting ferroptosis may offer new therapeutic strategies for managing diabetes.

Area of Science:

  • Biomedical Science
  • Cell Biology
  • Metabolic Disorders

Background:

  • The global prevalence of diabetes mellitus (DM) and its associated complications presents a significant public health challenge.
  • Understanding the underlying mechanisms of DM pathogenesis is crucial for developing effective treatments.

Purpose of the Study:

  • To review the role of ferroptosis in the development and progression of diabetes and its complications.
  • To summarize the regulatory mechanisms of ferroptosis in diabetes.
  • To discuss potential therapeutic strategies targeting ferroptosis for diabetic patients.

Main Methods:

  • Literature review of recent studies on ferroptosis and diabetes.
  • Analysis of the molecular pathways involved in ferroptosis.
  • Synthesis of findings on ferroptosis inhibitors in the context of diabetes.

Main Results:

  • Ferroptosis, characterized by reactive oxygen species production and iron imbalance, is implicated in diabetes pathogenesis.
  • Specific regulatory mechanisms of ferroptosis in diabetes and its complications have been identified.
  • Several inhibitors of ferroptosis show potential for treating diabetes and related conditions.

Conclusions:

  • Ferroptosis plays a critical role in diabetes and its complications.
  • Targeting ferroptosis pathways presents a promising avenue for novel therapeutic interventions in diabetes management.
Keywords:
diabetesdiabetic complicationsdiabetic kidney diseaseferroptosisiron

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