Surgery improves survival in bladder signet-ring cell carcinoma-a population-based study

Area of Science:

• Urology
• Surgical Oncology
• Cancer Research

Background:

• Signet ring cell carcinoma (SRCC) of the urinary bladder is a rare and aggressive subtype.
• The prognostic value of surgical intervention in bladder SRCC has not been well-established.
• Limited data exists on the comparative effectiveness of different treatment modalities for bladder SRCC.

Purpose of the Study:

• To evaluate the therapeutic value and prognostic significance of surgery in patients diagnosed with urinary bladder SRCC.
• To compare survival outcomes between patients with bladder SRCC who underwent surgery versus those who did not.
• To assess the impact of surgical treatment on overall survival (OS) and cause-specific survival (CSS).

Main Methods:

• Retrospective analysis of 595 patients with urinary bladder SRCC from the Surveillance, Epidemiology, and End Results (SEER) program (1975-2018).
• Patients were divided into two groups: 496 who underwent surgery and 99 who did not.
• Univariate and multivariate Cox regression models were employed to analyze the effect of surgical therapy on CSS and OS, adjusting for multiple clinical variables.

Main Results:

• Surgery was associated with significantly better OS and CSS compared to non-surgical management (p=0.001).
• Multivariate analysis confirmed surgery as an independent predictor of improved survival (HR=0.592; 95% CI=0.449-0.782; p=0.0001).
• Surgical intervention demonstrated superior survival outcomes compared to chemotherapy and radiation alone.

Conclusions:

• Surgical treatment is a significant independent predictor of improved survival in urinary bladder SRCC.
• Patients undergoing surgery exhibit higher cause-specific survival and overall survival rates.
• Surgery offers a survival advantage over other treatment modalities for bladder SRCC.