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Author Spotlight: Exploring the Lifespan Dynamics of Healthy Human Hematopoiesis

Author Spotlight: Exploring the Lifespan Dynamics of Healthy Human Hematopoiesis

Published on: December 8, 2023

Prophylaxis use of vitamin K1 improves coagulation function in hematopoietic stem cell transplantation patients: a

Yi Zhang¹, Xuan Lu¹, Liang V Tang¹

¹Institute of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology Wuhan, China.

American Journal of Translational Research

|April 15, 2022

Objectives:

This study aimed to investigate the efficacy of vitamin K1 in patients undergoing HSCT and find a feasible and safe option for HSCT patients to prevent bleeding.

Methods:

A retrospective analysis was performed on 96 HSCT patients admitted to the Department of Hematology of Wuhan Union Hospital from January 2018 to July 2019. Patients were divided into two groups (the vitamin K1 group and the control group) based on the administration of vitamin K1. All patients were reexamined for coagulation function during their hospitalization. The prothrombin time (PT), activated partial thromboplastin time (APTT), and plasma fibrinogen (FIB) were measured. The relationship between plasma infusion volumes were also analyzed.

Results:

In the independent sample T-test analysis, PT and APTT of the vitamin K1 group were significantly shorter than that of the control group after transplantation. There was no obvious difference in plasma FIB levels between the two groups. Total plasma infused volume in the vitamin K1 group was significantly lower than that in the control group.

Conclusions:

Prophylactic intravenous drip of vitamin K1 has a good therapeutic effect on improving the coagulation function in HSCT patients without significant side effects and decreases the plasma transfusion.

Keywords:

Vitamin K1 blood coagulation blood transfusion hematopoietic stem cell transplantation hemostasis

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