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Two indirect tests of exocrine pancreatic function evaluated.

S Scharpé, L Iliano

    Clinical Chemistry
    |January 1, 1987
    PubMed
    Summary

    The pancreolauryl test and N-benzoyl-L-tyrosyl-p-aminobenzoic acid (NBT-PABA) test assess exocrine pancreatic function. The pancreolauryl test shows better specificity and sensitivity than NBT-PABA.

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    Area of Science:

    • Gastroenterology
    • Biochemistry
    • Medical Diagnostics

    Background:

    • Exocrine pancreatic function is crucial for digestion and nutrient absorption.
    • Indirect assessment methods are valuable for diagnosing pancreatic disorders.
    • Accurate functional assessment aids in managing conditions like cystic fibrosis and pancreatitis.

    Purpose of the Study:

    • To describe and evaluate two indirect methods for assessing exocrine pancreatic function: the N-benzoyl-L-tyrosyl-p-aminobenzoic acid (NBT-PABA) test and the pancreolauryl test.
    • To compare the diagnostic utility and performance characteristics of these two tests.

    Main Methods:

    • Oral administration of a specific substrate to patients.
    • Measurement of metabolized products excreted in urine following pancreatic enzyme action.
    • Comparative analysis of NBT-PABA and pancreolauryl test results.

    Main Results:

    • Both tests involve oral substrate administration and urinary metabolite measurement.
    • The pancreolauryl test demonstrated superior specificity and sensitivity compared to the NBT-PABA test.
    • The pancreolauryl test is less susceptible to drug interference and independent of renal function.

    Conclusions:

    • The pancreolauryl test is a reliable and robust method for assessing exocrine pancreatic function.
    • It offers advantages over the NBT-PABA test in terms of accuracy and ease of use.
    • Both tests are applicable in diagnosing and monitoring pancreatic diseases and enzyme replacement therapy.

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