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Updated: Sep 27, 2025
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Visualizing and Quantifying Pharmaceutical Compounds within Skin using Coherent Raman Scattering Imaging
Published on: November 24, 2021
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Vesicular systems for dermal and transdermal drug delivery
Claire Richard1, Stéphanie Cassel1, Muriel Blanzat1
1Laboratoire des Interactions Moléculaires et Réactivité Chimique et Photochimique, UMR 5623, Université Paul Sabatier 31062 Toulouse Cedex 4 France blanzat@chimie.ups-tlse.fr.
RSC Advances
|April 15, 2022
Summary
This review explores advanced vesicular systems for dermal and transdermal drug delivery. It highlights strategies to enhance skin penetration and optimize drug efficacy while minimizing systemic absorption.
Area of Science:
- Pharmacology
- Materials Science
- Dermatology
Background:
- Dermal/transdermal drug delivery is crucial for enhancing therapeutic effects and reducing toxicity by limiting systemic drug absorption.
- This necessitates the development and optimization of diverse drug delivery carriers.
- Understanding skin structure and diffusion parameters is key to effective topical delivery.
Purpose of the Study:
- To review skin structure and factors influencing drug diffusion.
- To explore advanced strategies for improving dermal drug delivery.
- To focus on vesicular systems as cutting-edge carriers for enhanced dermal/transdermal transport.
Main Methods:
- Literature review of skin physiology and drug diffusion.
- Analysis of various drug delivery carriers, with emphasis on vesicular systems.
- Evaluation of state-of-the-art and emerging trends in dermal delivery vectors.
Main Results:
- Identification of key skin parameters affecting drug penetration.
- Overview of diverse strategies to enhance dermal drug delivery.
- Detailed examination of vesicular systems and their potential in transdermal applications.
Conclusions:
- Vesicular systems represent advanced vectors for dermal/transdermal drug delivery.
- Optimizing carrier properties is essential for improving cutaneous and transcutaneous drug penetration.
- Further research into ideal carrier characteristics will advance topical therapeutic strategies.
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