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Updated: Sep 27, 2025

Microwave-Assisted Preparation of 1-Aryl-1H-pyrazole-5-amines
Published on: June 23, 2019
Access and modulation of substituted 1-methyl-1,6-dihydropyrazolo[3,4-c]pyrazoles
Nicu-Cosmin Ostache1,2, Marie-Aude Hiebel1, Adriana-Luminiţa Fînaru2
1Institut de Chimie Organique et Analytique (ICOA), Université d'Orléans, UMR CNRS 7311 BP 6759 45067 Orléans Cedex 2 France franck.suzenet@univ-orleans.fr.
Abstract:
Despite the pharmacological potential of the pyrazolo[3,4-c]pyrazoles, only a few methods of preparation and direct functionalization of this moiety have been described. We report herein a convenient design of new pyrazolo[3,4-c]pyrazoles with a high therapeutic impact. The effective chosen strategy consists of hydrazine condensations and C-N Ullmann-type cross-coupling reactions with microwave activation. Moreover, chemoselective bromination of the newly formed bipyrazoles followed by Suzuki-Miyaura cross-coupling reactions allowed the synthesis of a variety of modulated heterobicycles.
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