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The Oxford Database of Perinatal Trials: developing a register of published reports of controlled trials
Insights
A new perinatal trials database is being developed to assess intervention safety and efficacy. This resource aims to improve research coordination and evidence-based perinatal care practices.
Area of Science:
- Perinatal Medicine
- Clinical Trials Methodology
- Evidence-Based Healthcare
Background:
- Perinatal care requires robust data on intervention safety and efficacy.
- Coordinated research efforts are crucial for advancing perinatal medicine.
- Existing resources may lack comprehensive trial data.
Purpose of the Study:
- To establish a comprehensive database of perinatal trials.
- To facilitate systematic reviews and meta-analyses of perinatal interventions.
- To foster collaborative research in the perinatal field.
Main Methods:
- Development of a register for published perinatal trial reports.
- Inclusion criteria and data extraction methods are being defined.
- Focus on creating a foundational element for a larger database.
Main Results:
- The initial phase focused on establishing the register of published trials.
- Methodologies for data collection and quality assessment are outlined.
- This forms the first component of a multi-element database.
Conclusions:
- The developed register is a key step towards a comprehensive perinatal trial resource.
- This initiative will support evidence-based practice and research collaboration.
- Further development will include unpublished, ongoing, and planned trials.
Abstract:
A database of perinatal trials is currently being established to provide a resource for reviews of the safety and efficacy of interventions used in perinatal care and to foster cooperative and coordinated research efforts in the perinatal field. The database will ultimately comprise four main elements: a register of published reports of trials; a register of unpublished trials; a register of ongoing and planned trials; and data derived from pooled overviews (meta-analyses) of trials. This article describes the development of the first of these four elements.