A facile and efficient route to one-pot synthesis of new cyclophanes using vinamidinium salts
Nooshin Golzar1, Abdolmohammad Mehranpour1, Najmeh Nowrouzi1
1Department of Chemistry, Faculty of Sciences, Persian Gulf University Bushehr 75169 Iran ammehranpour@hotmail.com.
Abstract:
In this study, an efficient method for the synthesis of new cyclophanes (5a-f, 6a-g) through the condensation of 1,4-phenylenedimethanamine (3) or 2,3,5,6-tetramethylbenzene-1,4-diamine (4) with 2-substituted vinamidiniums (2a-g) is described. The cyclophane derivatives are obtained in good to excellent yields in the presence of acetic acid in refluxing acetonitrile after 15 h. The structure of new compounds was validated based on their spectral data (1H NMR, 13C NMR, IR) and elemental analysis.
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