Arenesulfonyl indole: new precursor for diversification of C-3 functionalized indoles
Banni Preet Kaur1, Jasneet Kaur2, Swapandeep Singh Chimni1
1Department of Chemistry, U.G.C. Centre of Advance Study-II, Guru Nanak Dev University Amritsar Punjab India sschimni@yahoo.com sschimni.chem@gndu.ac.in.
Abstract:
Arenesulfonyl indoles, bearing a good leaving group, are effective precursors for vinylogous imine intermediates which are generated in situ under basic conditions. This intermediate can readily react with other nucleophilic reagents to obtain C-3 substituted indole derivatives. In the last few years, a plethora of exciting synthetic applications of this substrate have been exploited. The stability of arylsulfonyl-containing substrates, mild reaction conditions, and the large variety of nucleophiles involved in these procedures are the key to their success in organic synthesis.
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