An efficient and practical aerobic oxidation of benzylic methylenes by recyclable N-hydroxyimide
Jian Wang1, Cheng Zhang2, Xiao-Qing Ye1
1School of Pharmacy, Hangzhou Medical College No. 481 Binwen Road, Binjiang District Hangzhou 310053 China 745811951@qq.com jian_wang@outlook.com ddwwtt@163.com.
Abstract:
An efficient and practical benzylic aerobic oxidation catalyzed by cheap and simple N-hydroxyimide organocatalyst has been achieved with high yields and broad substrate scope. The organocatalyst used can be recycled and reused by simple workup and only minute amount (1 mol% in most cases) of simple iron salt is used as promoter. Phenyl substrates with mild and strong electron-withdrawing group could also be oxygenated in high yields as well as other benzylic methylenes. Influence of substituents, gram-scale application, catalysts decay and general mechanism of this methodology has also been discussed.
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