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Updated: Sep 27, 2025

Construction and Systematical Symmetric Studies of a Series of Supramolecular Clusters with Binary or Ternary Ammonium Triphenylacetates
Published on: February 15, 2016
Investigations into the structure-activity relationship in gemini QACs based on biphenyl and oxydiphenyl linker
Anatoly N Vereshchagin1, Nikita A Frolov1, Valeria Yu Konyuhova1
1N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences 47 Leninsky Procpekt 119991 Moscow Russia vereshchagin@ioc.ac.ru.
Abstract:
Eighteen novel gemini quaternary ammonium compounds were synthesized to examine the effect of linker nature, aliphatic chain length and their relative position on antibacterial and antifungal activity. The synthesized compounds showed strong bacteriostatic activity against a panel of both Gram-positive and Gram-negative bacteria, including methicillin-resistant Staphylococcus aureus (MRSA) and two fungi. Some of these compounds exhibited a wider and more potent antimicrobial spectrum than commonly-used antiseptics, such as benzalkonium chloride (BAC), cetylpyridinium chloride (CPC), chlorhexidine digluconate (CHG) and octenidine dihydrochloride (OCT).
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