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Updated: Sep 27, 2025

Facile Preparation of 4-Substituted Quinazoline Derivatives
Published on: February 15, 2016
An efficient synthesis of 4-phenoxy-quinazoline, 2-phenoxy-quinoxaline, and 2-phenoxy-pyridine derivatives using
Mahesh K Zilla1,2, Sheena Mahajan2, Rajni Khajuria3
1Department of Chemical Sciences, Indian Institute of Science Education and Research (IISER) Berhampur Odisha 760010 India mzilla@iiserbpr.ac.in.
Abstract:
Herein we report the mild and efficient synthesis of 4-phenoxyquinazoline, 2-phenoxyquinoxaline, and 2-phenoxypyridine derivatives from the starting materials viz. quinazolin-4(3H)-one, quinoxalin-2(1H)-one, and pyridin-2(1H)-one and aryne generated in situ from 2-(trimethylsilyl)phenyl trifluoromethanesulfonate and cesium fluoride. This synthetic methodology gives a new environmentally benign way for the preparation of several unnatural series of 4-phenoxyquinazoline, 2-phenoxyquinoxaline and 2-phenoxypyridine compounds with high yields and broad substrate scope.
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