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Silver nanoparticle@carbon quantum dot composite as an antibacterial agent.

Tianyu Liu1, Qianyue Pang2, Kang Mai3

  • 1School of Pharmacy, Guangdong Pharmaceutical University Guangzhou 510006 China liuyi915@126.com.

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|April 15, 2022
PubMed
Summary
This summary is machine-generated.

A novel silver nanoparticles@sulfur, nitrogen-codoped carbon quantum dots (AgNPs@S,N-CQDs) composite exhibits potent antibacterial activity against common pathogens. This material demonstrates good biocompatibility, suggesting its potential as a safe and effective antibacterial agent.

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Area of Science:

  • Materials Science
  • Nanotechnology
  • Biomedical Engineering

Background:

  • The emergence of antibiotic-resistant bacteria necessitates the development of novel antimicrobial agents.
  • Silver nanoparticles (AgNPs) are known for their broad-spectrum antibacterial properties.
  • Carbon quantum dots (CQDs) offer unique optical and electronic properties, with potential applications in biomedicine.

Purpose of the Study:

  • To synthesize and characterize a novel AgNPs@S,N-CQDs composite material.
  • To evaluate the antibacterial efficacy of the composite against various pathogens.
  • To investigate the biocompatibility of the AgNPs@S,N-CQDs composite.

Main Methods:

  • One-step synthesis of AgNPs@S,N-CQDs composite.
  • Characterization of particle size, uniformity, and stability.
  • Antibacterial assays against *S. aureus*, *E. coli*, MRSA, and *C. albicans*.
  • Minimum inhibitory concentration (MIC) determination.
  • Reactive oxygen species (ROS) generation assessment using DCFH-DA kit.
  • Biocompatibility testing with HepG2 cells.

Main Results:

  • Uniform and stable AgNPs naturally surrounded by S,N-CQDs were successfully synthesized.
  • The composite demonstrated significant antibacterial activity against *S. aureus*, *E. coli*, MRSA, and *C. albicans*.
  • MIC values were found to be 63 μg mL⁻¹ for *S. aureus* and MRSA, and 32 μg mL⁻¹ for *E. coli* and *C. albicans*.
  • Antibacterial effect was attributed to ROS generation, confirmed by DCFH-DA assay.
  • The composite exhibited good biocompatibility with HepG2 cells.

Conclusions:

  • The synthesized AgNPs@S,N-CQDs composite possesses excellent antibacterial properties.
  • The material's mechanism of action involves ROS generation.
  • Promising biocompatibility suggests potential for clinical applications.
  • AgNPs@S,N-CQDs composite is a viable candidate for a new generation of antibacterial agents.