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Synthesis of a Thiol Building Block for the Crystallization of a Semiconducting Gyroidal Metal-sulfur Framework
Published on: April 9, 2018
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Transition-metal-catalyzed remote C-H functionalization of thioethers
Xiao-Qing Feng1, He-Cheng Wang1, Zhi Li2
1School of Pharmacy & School of Medicine, Changzhou University Changzhou Jiangsu 213164 China.
RSC Advances
|April 15, 2022
Summary
Transition-metal catalysis enables efficient derivatization of thioethers via direct C-H bond functionalization. This review covers advances in remote C-H functionalization of thioethers from 2010-2021, detailing both mono- and bidentate-directing group strategies.
Area of Science:
- Organic Chemistry
- Catalysis
- Synthetic Methodology
Background:
- Direct C-H bond functionalization is a key strategy for thioether derivatization.
- Transition-metal catalysis offers efficient routes for modifying thioether compounds.
- Remote C-H functionalization allows for targeted modifications at specific positions within thioethers.
Purpose of the Study:
- To systematically review advances in transition-metal-catalyzed remote C-H functionalization of thioethers.
- To cover developments from 2010 to 2021.
- To elucidate the mechanisms behind these functionalization strategies.
Main Methods:
- Review of literature on transition-metal-catalyzed reactions.
- Analysis of mono- and bidentate-directing group strategies.
- Examination of C(sp2)-H and C(sp3)-H functionalization of thioethers.
Main Results:
- Significant progress in remote C-H functionalization of thioethers has been achieved.
- Both mono- and bidentate-directing groups enable distinct functionalization pathways.
- Mechanistic insights into these transformations have been established.
Conclusions:
- Transition-metal-catalyzed remote C-H functionalization is a powerful tool for thioether derivatization.
- Understanding directing group strategies is crucial for selective functionalization.
- The field has seen substantial advancements in the last decade, offering new synthetic possibilities.
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