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Updated: Sep 27, 2025

Facile Preparation of 4-Substituted Quinazoline Derivatives
Published on: February 15, 2016
Straightforward synthesis of quinazolin-4(3H)-ones via visible light-induced condensation cyclization
Wuji Sun1, Xue Ma1, Yuqi Pang1
1School of Pharmacy, North China University of Science and Technology Tangshan 063210 China chunyanliu@ncst.edu.cn.
Abstract:
A green, simple and efficient method is developed for the synthesis of quinazolin-4(3H)-ones via visible light-induced condensation cyclization of 2-aminobenzamides and aldehydes under visible light irradiation. The reaction proceeds using fluorescein as a photocatalyst in the presence of TBHP without the need for a metal catalyst. In addition, this reaction tolerates a broad scope of substrates and could afford a variety of desirable products in good to excellent yields. Thus, the present synthetic method provides a straightforward strategy for the synthesis of quinazolin-4(3H)-ones.
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