Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Bis-prodrug cryopreserved lipid nanoparticles with enzymatically triggered release.

Nanoscale advances·2026
Same author

The synthesis of indomethacin prodrugs for the formation of nanosuspensions by emulsion templated freeze drying.

RSC advances·2025
Same author

Solvent-Based Recycling as a Waste Management Strategy for Fibre-Reinforced Polymers: Current State of the Art.

Polymers·2025
Same author

Capturing the dynamic integrity of carbocyanine fluorophore-based lipid nanoparticles using the FRET technique.

Journal of materials chemistry. B·2025
Same author

Controlling enzyme hydrolysis of branched polymers synthesised using transfer-dominated branching radical telomerisation via telogen and taxogen selection.

Communications chemistry·2024
Same author

Employing transfer-dominated branching radical telomerisation (TBRT) and atom transfer radical polymerisation (ATRP) to form complex polyester-polymethacrylate branched-linear star copolymer hybrids <i>via</i> orthogonal initiation.

Chemical communications (Cambridge, England)·2024
Same journal

A multifunctional octacalcium phosphate pentahydrate with dual environmental and biomedical functions: efficient dye removal, potent antimicrobial activity, and ionic regulation in physiological media.

RSC advances·2026
Same journal

Research progress on immobilized penicillin G acylase and industrial applications.

RSC advances·2026
Same journal

Recycling of expired Ceporex drug (CPX) as a corrosion inhibitor for carbon steel in a hydrochloric acid medium.

RSC advances·2026
Same journal

Fibrillation/defibrillation of myoglobin decorated with gold nanoparticles probed through nanometal surface energy transfer mechanism.

RSC advances·2026
Same journal

Recent advances in the synthesis and applications of cyanuric acid and its related analogues: a comprehensive review.

RSC advances·2026
Same journal

Effects of fluid flow and solute transport on anorthite dissolution rates in heterogeneous pore networks.

RSC advances·2026
See all related articles

Related Experiment Video

Updated: Sep 27, 2025

Synthesis of Stimuli-responsive Nanogels using Aqueous One-step Crosslinking and Co-nanopolymerization
06:26

Synthesis of Stimuli-responsive Nanogels using Aqueous One-step Crosslinking and Co-nanopolymerization

Published on: January 24, 2025

1.3K

Dual-responsive degradable core-shell nanogels with tuneable aggregation behaviour.

Dominic M Gray1, Adam R Town1, Edyta Niezabitowska1

  • 1Department of Chemistry, University of Liverpool Crown Street L69 7ZD UK Thomas.Mcdonald@liverpool.ac.uk Dominic.Gray@liverpool.ac.uk.

RSC Advances
|April 15, 2022
PubMed
Summary
This summary is machine-generated.

Core-shell nanogels synthesized from N-isopropylacrylamide (NIPAM) and N-isopropylmethacrylamide (NIPMAM) show tunable aggregation. Degradable nanogels demonstrate significant breakdown with reducing agents, suggesting nanomedicine applications.

More Related Videos

Fabricating Degradable Thermoresponsive Hydrogels on Multiple Length Scales via Reactive Extrusion, Microfluidics, Self-assembly, and Electrospinning
12:07

Fabricating Degradable Thermoresponsive Hydrogels on Multiple Length Scales via Reactive Extrusion, Microfluidics, Self-assembly, and Electrospinning

Published on: April 16, 2018

13.6K
Alternating Magnetic Field-Responsive Hybrid Gelatin Microgels for Controlled Drug Release
09:11

Alternating Magnetic Field-Responsive Hybrid Gelatin Microgels for Controlled Drug Release

Published on: February 13, 2016

9.9K

Related Experiment Videos

Last Updated: Sep 27, 2025

Synthesis of Stimuli-responsive Nanogels using Aqueous One-step Crosslinking and Co-nanopolymerization
06:26

Synthesis of Stimuli-responsive Nanogels using Aqueous One-step Crosslinking and Co-nanopolymerization

Published on: January 24, 2025

1.3K
Fabricating Degradable Thermoresponsive Hydrogels on Multiple Length Scales via Reactive Extrusion, Microfluidics, Self-assembly, and Electrospinning
12:07

Fabricating Degradable Thermoresponsive Hydrogels on Multiple Length Scales via Reactive Extrusion, Microfluidics, Self-assembly, and Electrospinning

Published on: April 16, 2018

13.6K
Alternating Magnetic Field-Responsive Hybrid Gelatin Microgels for Controlled Drug Release
09:11

Alternating Magnetic Field-Responsive Hybrid Gelatin Microgels for Controlled Drug Release

Published on: February 13, 2016

9.9K

Area of Science:

  • Polymer Chemistry
  • Materials Science
  • Nanotechnology

Background:

  • Thermoresponsive polymers are crucial for developing smart materials.
  • Core-shell nanostructures offer unique properties for drug delivery and diagnostics.
  • Controlling nanogel aggregation and degradation is key for advanced applications.

Purpose of the Study:

  • To synthesize and characterize core-shell nanogels using N-isopropylacrylamide (NIPAM) and N-isopropylmethacrylamide (NIPMAM).
  • To investigate the influence of monomer ratio on the aggregation behavior of nanogels in salt solutions.
  • To evaluate the degradability of nanogels incorporating a bis(acryloyl)cystamine (BAC) cross-linker in response to reducing agents.

Main Methods:

  • Sequential monomer addition for core-shell nanogel synthesis.
  • Dynamic light scattering and other techniques to study aggregation.
  • Degradation studies using varying concentrations of reducing agents at physiological pH.

Main Results:

  • Tunable aggregation of nanogels achieved by altering the NIPAM/NIPMAM ratio.
  • Core-shell nanogels with BAC exhibited significant degradation in the presence of reducing agents.
  • Copolymer nanogels showed lower degradation rates compared to core-shell counterparts.
  • Degradation was effective at physiologically relevant reducing agent concentrations and pH 7.

Conclusions:

  • Core-shell nanogels offer tunable aggregation and controlled degradation properties.
  • The degradable nature of these nanogels, particularly at physiological conditions, is promising.
  • Potential applications in nanomedicine, such as targeted drug delivery and responsive systems, are highlighted.