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Copper-assisted preparation of pyridinyl sulfonate esters from hydroxypyridines and sodium sulfinates
Qian Li1, Haibo Zhu1,2, Yishuai Liu1
1Jiangxi Province Key Laboratory of Synthetic Chemistry, School of Chemistry, Biology and Material Science, East China University of Technology 330013 Nanchang China hbzhu@ecut.edu.cn fanqw2019@ecut.edu.cn zbxie@ecut.edu.cn.
Abstract:
An efficient and powerful copper-assisted method for the effective conversion of a broad range of hydroxypyridines and sodium sulfinates into their corresponding pyridinyl tosylates was developed. Key features of this base- and ligand-free protocol include using the cheap and readily available CuBr2 as a medium and the use of sodium sulfinates as formal sulfonylation reagents. A variety of functional pyridinyl tosylates could be formed with good yields, which can easily be converted into C-C and C-N bond-containing compounds.
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