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Published on: May 12, 2023
Acridine-based dyes as high-performance near-infrared Raman reporter molecules for cell imaging
Jiasheng Du1, Jinming Li1, Yuzhan Li1
1Department of Materials Physics and Chemistry, School of Materials Science and Engineering, University of Science and Technology Beijing Beijing 100083 China.
Abstract:
A surface-enhanced Raman scattering (SERS) nanoprobe has been proven to be a promising tool for near-infrared (NIR) biomedical imaging and diagnosis because of its high sensitivity and selectivity. However, the development of NIR SERS reporters has been a bottleneck impeding the preparation of ultrasensitive SERS probes. Herein, we report the design and synthesis of a series of SERS reporters in the NIR region based on 10-methylacridine (AD). The AD nanotags (gold nanostar-AD molecules-BSA, AuNS-AD-BSA) exhibit appreciable SERS signals and can be detected at as low as the sub-picomole level. The results of in vitro imaging experiments show that it can be used in live-cell delineation.
