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Decrease in number of hippocampal gamma-aminobutyric acid (GABA) immunoreactive cells in the rat kindling model of
Experimental Brain Research
|January 1, 1986
Abstract:
Daily repeated tetanic electrical stimulation (kindling) of hippocampus or other brain structures leads to progressive increase in epileptiform activity. Since kindling may involve changes in the inhibitory neurotransmitter gamma-aminobutyric acid (GABA), the distribution of this amino acid was studied. A significant decrease in number of GABA immunoreactive positive cell bodies in stimulated CA1 region of the rat hippocampus compared to the contralateral side was found.